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Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema
Joint Authors
Hilty, Matthias Peter
Zügel, Stefanie
Schoeb, Michele
Auinger, Katja
Dehnert, Christoph
Maggiorini, Marco
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Acute exposure to high altitude induces inflammation.
However, the relationship between inflammation and high altitude related illness such as high altitude pulmonary edema (HAPE) and acute mountain sickness (AMS) is poorly understood.
We tested if soluble urokinase-type plasminogen activator receptor (suPAR) plasma concentration, a prognostic factor for cardiovascular disease and marker for low grade activation of leukocytes, will predict susceptibility to HAPE and AMS.
Methods.
41 healthy mountaineers were examined at sea level (SL, 446 m) and 24 h after rapid ascent to 4559 m (HA).
24/41 subjects had a history of HAPE and were thus considered HAPE-susceptible (HAPE-s).
Out of the latter, 10/24 HAPE-s subjects were randomly chosen to suppress the inflammatory cascade with dexamethasone 8 mg bid 24 h prior to ascent.
Results.
Acute hypoxic exposure led to an acute inflammatory reaction represented by an increase in suPAR ( 1.9 ± 0.4 at SL versus 2.3 ± 0.5 at HA, p < 0.01 ), CRP ( 0.7 ± 0.5 at SL versus 3.6 ± 4.6 at HA, p < 0.01 ), and IL-6 ( 0.8 ± 0.4 at SL versus 3.3 ± 4.9 at HA, p < 0.01 ) in all subjects except those receiving dexamethasone.
The ascent associated decrease in PaO2 correlated with the increase in IL-6 ( r = 0.46 , p < 0.001 ), but not suPAR ( r = 0.27 , p = 0.08 ); the increase in IL-6 was not correlated with suPAR ( r = 0.16 , p = 0.24 ).
Baseline suPAR plasma concentration was higher in the HAPE-s group ( 2.0 ± 0.4 versus 1.8 ± 0.4 , p = 0.04 ); no difference was found for CRP and IL-6 and for subjects developing AMS.
Conclusion.
High altitude exposure leads to an increase in suPAR plasma concentration, with the missing correlation between suPAR and IL-6 suggesting a cytokine independent, leukocyte mediated mechanism of low grade inflammation.
The correlation between IL-6 and PaO2 suggests a direct effect of hypoxia, which is not the case for suPAR.
However, suPAR plasma concentration measured before hypoxic exposure may predict HAPE susceptibility.
American Psychological Association (APA)
Hilty, Matthias Peter& Zügel, Stefanie& Schoeb, Michele& Auinger, Katja& Dehnert, Christoph& Maggiorini, Marco. 2016. Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1110955
Modern Language Association (MLA)
Hilty, Matthias Peter…[et al.]. Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1110955
American Medical Association (AMA)
Hilty, Matthias Peter& Zügel, Stefanie& Schoeb, Michele& Auinger, Katja& Dehnert, Christoph& Maggiorini, Marco. Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1110955
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110955