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Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury
المؤلفون المشاركون
Chen, Bi-Cheng
Lu, Hong
Bai, Yongyu
Wu, Lianfeng
Hong, Weilong
Liang, Yong
Bai, Yongheng
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-23
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Macrophage migration inhibitory factor (MIF) is an important immunoregulatory cytokine involved in inflammation, which may be one important reason resulting in matrix deposition in renal tissues after injury.
However, the underlying mechanisms have not yet been elucidated.
Methods and Results.
We uncovered a crucial role of MIF in inflammation and collagen deposition in vivo and in vitro.
In rats, ureteral obstruction induced tubular injury, matrix accumulation, and inflammatory cell infiltration.
Additionally, enhanced MIF levels in the obstructed kidneys were closely related to the increasing numbers of CD68-positive macrophages.
These obstruction-induced injuries can be relieved by recanalization, consequently resulting in downregulated expression of MIF and its receptor CD74.
Similarly, ischemia reperfusion induced renal injury, and it was accompanied by elevated MIF levels and macrophages infiltration.
In cultured tubular epithelial cells (TECs), aristolochic acid (AA) promoted matrix production and increased MIF expression, as well as the release of macrophage-related factors.
Inhibition of MIF with an antagonist ISO-1 resulted in the abolishment of these genotypes in AA-treated TECs.
Conclusion.
MIF plays an important role in macrophage-related inflammation and matrix deposition in kidney tissues following injury.
MIF as a specific inhibitor may have therapeutic potential for patients with inflammatory and fibrotic kidney diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Hong& Bai, Yongyu& Wu, Lianfeng& Hong, Weilong& Liang, Yong& Chen, Bi-Cheng…[et al.]. 2016. Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110960
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Hong…[et al.]. Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1110960
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Hong& Bai, Yongyu& Wu, Lianfeng& Hong, Weilong& Liang, Yong& Chen, Bi-Cheng…[et al.]. Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110960
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110960
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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