Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury
Joint Authors
Chen, Bi-Cheng
Lu, Hong
Bai, Yongyu
Wu, Lianfeng
Hong, Weilong
Liang, Yong
Bai, Yongheng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Macrophage migration inhibitory factor (MIF) is an important immunoregulatory cytokine involved in inflammation, which may be one important reason resulting in matrix deposition in renal tissues after injury.
However, the underlying mechanisms have not yet been elucidated.
Methods and Results.
We uncovered a crucial role of MIF in inflammation and collagen deposition in vivo and in vitro.
In rats, ureteral obstruction induced tubular injury, matrix accumulation, and inflammatory cell infiltration.
Additionally, enhanced MIF levels in the obstructed kidneys were closely related to the increasing numbers of CD68-positive macrophages.
These obstruction-induced injuries can be relieved by recanalization, consequently resulting in downregulated expression of MIF and its receptor CD74.
Similarly, ischemia reperfusion induced renal injury, and it was accompanied by elevated MIF levels and macrophages infiltration.
In cultured tubular epithelial cells (TECs), aristolochic acid (AA) promoted matrix production and increased MIF expression, as well as the release of macrophage-related factors.
Inhibition of MIF with an antagonist ISO-1 resulted in the abolishment of these genotypes in AA-treated TECs.
Conclusion.
MIF plays an important role in macrophage-related inflammation and matrix deposition in kidney tissues following injury.
MIF as a specific inhibitor may have therapeutic potential for patients with inflammatory and fibrotic kidney diseases.
American Psychological Association (APA)
Lu, Hong& Bai, Yongyu& Wu, Lianfeng& Hong, Weilong& Liang, Yong& Chen, Bi-Cheng…[et al.]. 2016. Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110960
Modern Language Association (MLA)
Lu, Hong…[et al.]. Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1110960
American Medical Association (AMA)
Lu, Hong& Bai, Yongyu& Wu, Lianfeng& Hong, Weilong& Liang, Yong& Chen, Bi-Cheng…[et al.]. Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110960
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110960