Antileishmanial Activity and Inducible Nitric Oxide Synthase Activation by RuNO Complex
المؤلفون المشاركون
Cataneo, Allan Henrique Depieri
Panis, Carolina
Kian, Danielle
Kawakami, Natalia Yoshie
Marcusso Orsini, Tatiane
Fortes dos Santos Thomazelli, Ana Paula
Tomiotto-Pellissier, Fernanda
Megumi Yamauchi, Lucy
Gouveia Júnior, Florêncio S.
de França Lopes, Luiz Gonzaga
Cecchini, Rubens
Nazareth Costa, Idessânia
Jerley Nogueira da Silva, Jean
Conchon-Costa, Ivete
Pavanelli, Wander Rogério
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Parasites of the genus Leishmania are capable of inhibiting effector functions of macrophages.
These parasites have developed the adaptive ability to escape host defenses; for example, they inactivate the NF-κB complex and suppress iNOS expression in infected macrophages, which are responsible for the production of the major antileishmanial substance nitric oxide (NO), favoring then its replication and successful infection.
Metal complexes with NO have been studied as potential compounds for the treatment of certain tropical diseases, such as ruthenium compounds, known to be exogenous NO donors.
In the present work, the compound cis-[Ru(bpy)2SO3(NO)]PF6, or RuNO, showed leishmanicidal activity directly and indirectly on promastigote forms of Leishmania (Leishmania) amazonensis.
In addition, treatment with RuNO increased NO production by reversing the depletion of NO caused by Leishmania.
We also found increased expression of Akt, iNOS, and NF-κB in infected and treated macrophages.
These results demonstrated that RuNO was able to kill the parasite by NO release and modulate the transcriptional capacity of the cell.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marcusso Orsini, Tatiane& Kawakami, Natalia Yoshie& Panis, Carolina& Fortes dos Santos Thomazelli, Ana Paula& Tomiotto-Pellissier, Fernanda& Cataneo, Allan Henrique Depieri…[et al.]. 2016. Antileishmanial Activity and Inducible Nitric Oxide Synthase Activation by RuNO Complex. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110972
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marcusso Orsini, Tatiane…[et al.]. Antileishmanial Activity and Inducible Nitric Oxide Synthase Activation by RuNO Complex. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1110972
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marcusso Orsini, Tatiane& Kawakami, Natalia Yoshie& Panis, Carolina& Fortes dos Santos Thomazelli, Ana Paula& Tomiotto-Pellissier, Fernanda& Cataneo, Allan Henrique Depieri…[et al.]. Antileishmanial Activity and Inducible Nitric Oxide Synthase Activation by RuNO Complex. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110972
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110972
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر