![](/images/graphics-bg.png)
Antileishmanial Activity and Inducible Nitric Oxide Synthase Activation by RuNO Complex
Joint Authors
Cataneo, Allan Henrique Depieri
Panis, Carolina
Kian, Danielle
Kawakami, Natalia Yoshie
Marcusso Orsini, Tatiane
Fortes dos Santos Thomazelli, Ana Paula
Tomiotto-Pellissier, Fernanda
Megumi Yamauchi, Lucy
Gouveia Júnior, Florêncio S.
de França Lopes, Luiz Gonzaga
Cecchini, Rubens
Nazareth Costa, Idessânia
Jerley Nogueira da Silva, Jean
Conchon-Costa, Ivete
Pavanelli, Wander Rogério
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Parasites of the genus Leishmania are capable of inhibiting effector functions of macrophages.
These parasites have developed the adaptive ability to escape host defenses; for example, they inactivate the NF-κB complex and suppress iNOS expression in infected macrophages, which are responsible for the production of the major antileishmanial substance nitric oxide (NO), favoring then its replication and successful infection.
Metal complexes with NO have been studied as potential compounds for the treatment of certain tropical diseases, such as ruthenium compounds, known to be exogenous NO donors.
In the present work, the compound cis-[Ru(bpy)2SO3(NO)]PF6, or RuNO, showed leishmanicidal activity directly and indirectly on promastigote forms of Leishmania (Leishmania) amazonensis.
In addition, treatment with RuNO increased NO production by reversing the depletion of NO caused by Leishmania.
We also found increased expression of Akt, iNOS, and NF-κB in infected and treated macrophages.
These results demonstrated that RuNO was able to kill the parasite by NO release and modulate the transcriptional capacity of the cell.
American Psychological Association (APA)
Marcusso Orsini, Tatiane& Kawakami, Natalia Yoshie& Panis, Carolina& Fortes dos Santos Thomazelli, Ana Paula& Tomiotto-Pellissier, Fernanda& Cataneo, Allan Henrique Depieri…[et al.]. 2016. Antileishmanial Activity and Inducible Nitric Oxide Synthase Activation by RuNO Complex. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110972
Modern Language Association (MLA)
Marcusso Orsini, Tatiane…[et al.]. Antileishmanial Activity and Inducible Nitric Oxide Synthase Activation by RuNO Complex. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1110972
American Medical Association (AMA)
Marcusso Orsini, Tatiane& Kawakami, Natalia Yoshie& Panis, Carolina& Fortes dos Santos Thomazelli, Ana Paula& Tomiotto-Pellissier, Fernanda& Cataneo, Allan Henrique Depieri…[et al.]. Antileishmanial Activity and Inducible Nitric Oxide Synthase Activation by RuNO Complex. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110972