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Genetic Ablation of Soluble TNF Does Not Affect Lesion Size and Functional Recovery after Moderate Spinal Cord Injury in Mice
المؤلفون المشاركون
Jørgensen, L. H.
Ellman, Ditte Gry
Degn, Matilda
Lund, Minna Christiansen
Clausen, Bettina Hjelm
Novrup, Hans Gram
Flæng, Simon Bertram
Suntharalingam, Lujitha
Svenningsen, Åsa Fex
Brambilla, Roberta
Lambertsen, Kate Lykke
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-14
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Traumatic spinal cord injury (SCI) is followed by an instant increase in expression of the microglial-derived proinflammatory cytokine tumor necrosis factor (TNF) within the lesioned cord.
TNF exists both as membrane-anchored TNF (mTNF) and as cleaved soluble TNF (solTNF).
We previously demonstrated that epidural administration of a dominant-negative inhibitor of solTNF, XPro1595, to the contused spinal cord resulted in changes in Iba1 protein expression in microglia/macrophages, decreased lesion volume, and improved locomotor function.
Here, we extend our studies using mice expressing mTNF, but no solTNF ( m T N F Δ / Δ ), to study the effect of genetic ablation of solTNF on SCI.
We demonstrate that TNF levels were significantly decreased within the lesioned spinal cord 3 days after SCI in m T N F Δ / Δ mice compared to littermates.
This decrease did, however, not translate into significant changes in other pro- and anti-inflammatory cytokines (IL-10, IL-1β, IL-6, IL-5, IL-2, CXCL1, CCL2, or CCL5), despite a tendency towards increased IL-10 and decreased IL-1β, TNFR1, and TNFR2 levels in m T N F Δ / Δ mice.
In addition, microglial and leukocyte infiltration, activation state (Iba1, CD11b, CD11c, CD45, and MHCII), lesion size, and functional outcome after moderate SCI were comparable between genotypes.
Collectively, our data demonstrate that genetic ablation of solTNF does not significantly modulate postlesion outcome after SCI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ellman, Ditte Gry& Degn, Matilda& Lund, Minna Christiansen& Clausen, Bettina Hjelm& Novrup, Hans Gram& Flæng, Simon Bertram…[et al.]. 2016. Genetic Ablation of Soluble TNF Does Not Affect Lesion Size and Functional Recovery after Moderate Spinal Cord Injury in Mice. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1110974
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ellman, Ditte Gry…[et al.]. Genetic Ablation of Soluble TNF Does Not Affect Lesion Size and Functional Recovery after Moderate Spinal Cord Injury in Mice. Mediators of Inflammation No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1110974
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ellman, Ditte Gry& Degn, Matilda& Lund, Minna Christiansen& Clausen, Bettina Hjelm& Novrup, Hans Gram& Flæng, Simon Bertram…[et al.]. Genetic Ablation of Soluble TNF Does Not Affect Lesion Size and Functional Recovery after Moderate Spinal Cord Injury in Mice. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1110974
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110974
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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