Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway
المؤلفون المشاركون
Lu, Jie
Li, Jingjing
Wang, Fan
Li, Sainan
Liu, Tong
Zhou, Yuqing
Zhang, Rong
Zhou, Shunfeng
Cheng, Keran
Xu, Shizan
Feng, Jiao
Wu, Liwei
Xia, Yujing
Zhou, Ying-Qun
Chen, Kan
Guo, Chuan-Yong
Weiqi, Dai
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-16
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Objective.
Shikonin possesses anti-inflammatory effects.
However, its function in concanavalin A-induced acute liver injury remains uncertain.
The aim of the present study was to investigate the functions of shikonin and its mechanism of protection on ConA-induced acute liver injury.
Materials and Methods.
Balb/C mice were exposed to ConA (20 mg/kg) via tail vein injection to establish acute liver injury; shikonin (7.5 mg/kg and 12.5 mg/kg) was intraperitoneally administered 2 h before the ConA injection.
The serum liver enzyme levels and the inflammatory cytokine levels were determined at 3, 6, and 24 h after ConA injection.
Results.
After the injection of ConA, inflammatory cytokines IL-1β, TNF-α, and IFN-γ were significantly increased.
Shikonin significantly ameliorated liver injury and histopathological changes and suppressed the release of inflammatory cytokines.
The expressions of Bcl-2 and Bax were markedly affected by shikonin pretreatment.
LC3, Beclin-1, and p-JNK expression levels were decreased in the shikonin-pretreated groups compared with the ConA-treated groups.
Shikonin attenuated ConA-induced liver injury by reducing apoptosis and autophagy through the inhibition of the JNK pathway.
Conclusion.
Our results indicated that shikonin pretreatment attenuates ConA-induced acute liver injury by inhibiting apoptosis and autophagy through the suppression of the JNK pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Yuqing& Zhou, Shunfeng& Weiqi, Dai& Chen, Kan& Wang, Fan& Lu, Jie…[et al.]. 2016. Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1110976
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Yuqing…[et al.]. Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway. Mediators of Inflammation No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1110976
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Yuqing& Zhou, Shunfeng& Weiqi, Dai& Chen, Kan& Wang, Fan& Lu, Jie…[et al.]. Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1110976
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110976
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر