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Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway
Joint Authors
Lu, Jie
Li, Jingjing
Wang, Fan
Li, Sainan
Liu, Tong
Zhou, Yuqing
Zhang, Rong
Zhou, Shunfeng
Cheng, Keran
Xu, Shizan
Feng, Jiao
Wu, Liwei
Xia, Yujing
Zhou, Ying-Qun
Chen, Kan
Guo, Chuan-Yong
Weiqi, Dai
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Objective.
Shikonin possesses anti-inflammatory effects.
However, its function in concanavalin A-induced acute liver injury remains uncertain.
The aim of the present study was to investigate the functions of shikonin and its mechanism of protection on ConA-induced acute liver injury.
Materials and Methods.
Balb/C mice were exposed to ConA (20 mg/kg) via tail vein injection to establish acute liver injury; shikonin (7.5 mg/kg and 12.5 mg/kg) was intraperitoneally administered 2 h before the ConA injection.
The serum liver enzyme levels and the inflammatory cytokine levels were determined at 3, 6, and 24 h after ConA injection.
Results.
After the injection of ConA, inflammatory cytokines IL-1β, TNF-α, and IFN-γ were significantly increased.
Shikonin significantly ameliorated liver injury and histopathological changes and suppressed the release of inflammatory cytokines.
The expressions of Bcl-2 and Bax were markedly affected by shikonin pretreatment.
LC3, Beclin-1, and p-JNK expression levels were decreased in the shikonin-pretreated groups compared with the ConA-treated groups.
Shikonin attenuated ConA-induced liver injury by reducing apoptosis and autophagy through the inhibition of the JNK pathway.
Conclusion.
Our results indicated that shikonin pretreatment attenuates ConA-induced acute liver injury by inhibiting apoptosis and autophagy through the suppression of the JNK pathway.
American Psychological Association (APA)
Zhou, Yuqing& Zhou, Shunfeng& Weiqi, Dai& Chen, Kan& Wang, Fan& Lu, Jie…[et al.]. 2016. Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1110976
Modern Language Association (MLA)
Zhou, Yuqing…[et al.]. Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway. Mediators of Inflammation No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1110976
American Medical Association (AMA)
Zhou, Yuqing& Zhou, Shunfeng& Weiqi, Dai& Chen, Kan& Wang, Fan& Lu, Jie…[et al.]. Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1110976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110976