GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway
المؤلفون المشاركون
Wang, Yajing
Lu, Ping
Zhang, Weifeng
Du, Qianming
Tang, Jingjing
Wang, Hong
Lu, Jinrong
Hu, Rong
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-23
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Nonresolving inflammation is one of the consistent features of the tumor microenvironment in the intestine and plays a critical role in the initiation and development of colon cancer.
Here we reported the inhibitory effects of GEN-27, a new derivative of genistein, on the inflammation-related colon cancer cell proliferation and delineated the mechanism of its action.
The results indicated that GEN-27 inhibited the proliferation of human colon tumor HCT116 cells stimulated by culture supernatants of LPS-induced human monocytes THP-1 cells and significantly decreased LPS-induced secretion of proinflammatory cytokines interleukin-6 and interleukin-1β in THP-1 cells.
The HCT116 cell proliferation elicited by THP-1-conditioned medium could be blocked by the interleukin-1 receptor antagonist (IL-1RA).
Further mechanistic study revealed that GEN-27 remarkably inhibited the nuclear translocation of NF- κ B and phosphorylation of I κ B and IKK α / β in both HCT116 and THP-1 cells.
In addition, GEN-27 markedly suppressed the HCT116 cell proliferation stimulated by IL-1β treatment, which was dependent on the inhibition of NF-κB/p65 nuclear localization, as verified by p65 overexpression and BAY 11-7082, an NF- κ B inhibitor.
Taken together, our findings established that GEN-27 modulated NF- κ B signaling pathway involved in inflammation-induced cancer cells proliferation and therefore could be a potential chemopreventive agent against inflammation-associated colon cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yajing& Lu, Ping& Zhang, Weifeng& Du, Qianming& Tang, Jingjing& Wang, Hong…[et al.]. 2016. GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1110981
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yajing…[et al.]. GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway. Mediators of Inflammation No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1110981
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yajing& Lu, Ping& Zhang, Weifeng& Du, Qianming& Tang, Jingjing& Wang, Hong…[et al.]. GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1110981
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1110981
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر