Epstein-Barr Virus-Induced Gene 3 (EBI3)‎ Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway

المؤلفون المشاركون

Liang, Yanfang
Chen, Qianqian
Du, Wenjing
Chen, Can
Li, Feifei
Yang, Jingying
Peng, Jianyu
Kang, Dongping
Lin, Bihua
Chai, Xingxing
Zhou, Keyuan
Zeng, Jincheng

المصدر

Mediators of Inflammation

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-05-10

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأمراض

الملخص EN

Epstein-Barr virus-induced gene 3 (EBI3) is a member of the interleukin-12 (IL-12) family structural subunit and can form a heterodimer with IL-27p28 and IL-12p35 subunit to build IL-27 and IL-35, respectively.

However, IL-27 stimulates whereas IL-35 inhibits antitumor T cell responses.

To date, little is known about the role of EBI3 in tumor microenvironment.

In this study, firstly we assessed EBI3, IL-27p28, IL-12p35, gp130, and p-STAT3 expression with clinicopathological parameters of colorectal cancer (CRC) tissues; then we evaluated the antitumor T cell responses and tumor growth with a EBI3 blocking peptide.

We found that elevated EBI3 may be associated with IL-12p35, gp130, and p-STAT3 to promote CRC progression.

EBI3 blocking peptide promoted antitumor cytotoxic T lymphocyte (CTL) response by inducing Granzyme B, IFN-γ production, and p-STAT3 expression and inhibited CRC cell proliferation and tumor growth to associate with suppressing gp130 and p-STAT3 expression.

Taken together, these results suggest that EBI3 may mediate a bidirectional reciprocal-regulation STAT3 signaling pathway to assist the tumor escape immune surveillance in CRC.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Liang, Yanfang& Chen, Qianqian& Du, Wenjing& Chen, Can& Li, Feifei& Yang, Jingying…[et al.]. 2016. Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111004

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Liang, Yanfang…[et al.]. Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111004

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Liang, Yanfang& Chen, Qianqian& Du, Wenjing& Chen, Can& Li, Feifei& Yang, Jingying…[et al.]. Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111004

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1111004