![](/images/graphics-bg.png)
Effects of Low-Dose and Long-Term Treatment with Erythromycin on Interleukin-17 and Interleukin-23 in Peripheral Blood and Induced Sputum in Patients with Stable Chronic Obstructive Pulmonary Disease
المؤلفون المشاركون
He, Zhiyi
Tan, Caimei
Huang, Huijuan
Zhang, Jianquan
Bai, Jing
Zhong, Xiao-Ning
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
To study the effects of low-dose and long-term treatment with erythromycin on IL-17 and IL-23, in peripheral blood and induced sputum, in patients with stable chronic obstructive pulmonary disease (COPD).
Methods.
Patients were randomly divided into placebo-treated group, group A (12 months of additive treatment with erythromycin, N = 18 ), and group B (6 months of additive treatment with erythromycin followed by 6 months of follow-up, N = 18 ).
Inflammatory cells in induced sputum, pulmonary function, and the 6-minute walk distance (6MWD) were analyzed.
Concentrations of IL-17 and IL-23 in peripheral blood and sputum were measured using enzyme-linked immunosorbent assays.
Results.
After treatment, sputum and peripheral blood concentrations of IL-17 and IL-23 significantly decreased in groups A and B compared with placebo-treated group.
There were no significant differences after erythromycin withdrawal at months 9 and 12 in group B compared with placebo-treated group.
An increase in 6MWD was observed after treatment.
Conclusions.
Erythromycin was beneficial and reduced airway inflammation in COPD patients.
Underlying mechanisms may involve inhibition of IL-17 and IL-23 mediated airway inflammation.
COPD patients treated with erythromycin for 6 months experienced improved exercise capacity.
Finally, treatment for 12 months may be more effective than treatment for 6 months.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tan, Caimei& Huang, Huijuan& Zhang, Jianquan& He, Zhiyi& Zhong, Xiao-Ning& Bai, Jing. 2016. Effects of Low-Dose and Long-Term Treatment with Erythromycin on Interleukin-17 and Interleukin-23 in Peripheral Blood and Induced Sputum in Patients with Stable Chronic Obstructive Pulmonary Disease. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111055
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tan, Caimei…[et al.]. Effects of Low-Dose and Long-Term Treatment with Erythromycin on Interleukin-17 and Interleukin-23 in Peripheral Blood and Induced Sputum in Patients with Stable Chronic Obstructive Pulmonary Disease. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111055
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tan, Caimei& Huang, Huijuan& Zhang, Jianquan& He, Zhiyi& Zhong, Xiao-Ning& Bai, Jing. Effects of Low-Dose and Long-Term Treatment with Erythromycin on Interleukin-17 and Interleukin-23 in Peripheral Blood and Induced Sputum in Patients with Stable Chronic Obstructive Pulmonary Disease. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111055
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111055
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)