Effects of Low-Dose and Long-Term Treatment with Erythromycin on Interleukin-17 and Interleukin-23 in Peripheral Blood and Induced Sputum in Patients with Stable Chronic Obstructive Pulmonary Disease
Joint Authors
He, Zhiyi
Tan, Caimei
Huang, Huijuan
Zhang, Jianquan
Bai, Jing
Zhong, Xiao-Ning
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
To study the effects of low-dose and long-term treatment with erythromycin on IL-17 and IL-23, in peripheral blood and induced sputum, in patients with stable chronic obstructive pulmonary disease (COPD).
Methods.
Patients were randomly divided into placebo-treated group, group A (12 months of additive treatment with erythromycin, N = 18 ), and group B (6 months of additive treatment with erythromycin followed by 6 months of follow-up, N = 18 ).
Inflammatory cells in induced sputum, pulmonary function, and the 6-minute walk distance (6MWD) were analyzed.
Concentrations of IL-17 and IL-23 in peripheral blood and sputum were measured using enzyme-linked immunosorbent assays.
Results.
After treatment, sputum and peripheral blood concentrations of IL-17 and IL-23 significantly decreased in groups A and B compared with placebo-treated group.
There were no significant differences after erythromycin withdrawal at months 9 and 12 in group B compared with placebo-treated group.
An increase in 6MWD was observed after treatment.
Conclusions.
Erythromycin was beneficial and reduced airway inflammation in COPD patients.
Underlying mechanisms may involve inhibition of IL-17 and IL-23 mediated airway inflammation.
COPD patients treated with erythromycin for 6 months experienced improved exercise capacity.
Finally, treatment for 12 months may be more effective than treatment for 6 months.
American Psychological Association (APA)
Tan, Caimei& Huang, Huijuan& Zhang, Jianquan& He, Zhiyi& Zhong, Xiao-Ning& Bai, Jing. 2016. Effects of Low-Dose and Long-Term Treatment with Erythromycin on Interleukin-17 and Interleukin-23 in Peripheral Blood and Induced Sputum in Patients with Stable Chronic Obstructive Pulmonary Disease. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111055
Modern Language Association (MLA)
Tan, Caimei…[et al.]. Effects of Low-Dose and Long-Term Treatment with Erythromycin on Interleukin-17 and Interleukin-23 in Peripheral Blood and Induced Sputum in Patients with Stable Chronic Obstructive Pulmonary Disease. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111055
American Medical Association (AMA)
Tan, Caimei& Huang, Huijuan& Zhang, Jianquan& He, Zhiyi& Zhong, Xiao-Ning& Bai, Jing. Effects of Low-Dose and Long-Term Treatment with Erythromycin on Interleukin-17 and Interleukin-23 in Peripheral Blood and Induced Sputum in Patients with Stable Chronic Obstructive Pulmonary Disease. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111055
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111055