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Adiponectin Inhibits LPS-Induced HMGB1 Release through an AMP Kinase and Heme Oxygenase-1-Dependent Pathway in RAW 264 Macrophage Cells
المؤلفون المشاركون
Elfeky, Mohamed
Kaede, Ryuji
Okamatsu-Ogura, Yuko
Kimura, Kazuhiro
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
High mobility group protein B1 (HMGB1) is a late inflammatory mediator that exaggerates septic symptoms.
Adiponectin, an adipokine, has potent anti-inflammatory properties.
However, possible effects of adiponectin on lipopolysaccharide- (LPS-) induced HMGB1 release are unknown.
The aim of this study was to investigate effects of full length adiponectin on HMGB1 release in LPS-stimulated RAW 264 macrophage cells.
Treatment of the cells with LPS alone significantly induced HMGB1 release associated with HMGB1 translocation from the nucleus to the cytosol.
However, prior treatment with adiponectin suppressed LPS-induced HMGB1 release and translocation.
The anti-inflammatory cytokine interleukin- (IL-) 10 similarly suppressed LPS-induced HMGB1 release.
Adiponectin treatment decreased toll-like receptor 4 (TLR4) mRNA expression and increased heme oxygenase- (HO-) 1 mRNA expression without inducing IL-10 mRNA, while IL-10 treatment decreased TLR2 and HMGB1 mRNA expression and increased the expression of IL-10 and HO-1 mRNA.
Treatment with the HO-1 inhibitor ZnPP completely prevented the suppression of HMGB1 release by adiponectin but only partially inhibited that induced by IL-10.
Treatment with compound C, an AMP kinase (AMPK) inhibitor, abolished the increase in HO-1 expression and the suppression of HMGB1 release mediated by adiponectin.
In conclusion, our results indicate that adiponectin suppresses HMGB1 release by LPS through an AMPK-mediated and HO-1-dependent IL-10-independent pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Elfeky, Mohamed& Kaede, Ryuji& Okamatsu-Ogura, Yuko& Kimura, Kazuhiro. 2016. Adiponectin Inhibits LPS-Induced HMGB1 Release through an AMP Kinase and Heme Oxygenase-1-Dependent Pathway in RAW 264 Macrophage Cells. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111116
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Elfeky, Mohamed…[et al.]. Adiponectin Inhibits LPS-Induced HMGB1 Release through an AMP Kinase and Heme Oxygenase-1-Dependent Pathway in RAW 264 Macrophage Cells. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1111116
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Elfeky, Mohamed& Kaede, Ryuji& Okamatsu-Ogura, Yuko& Kimura, Kazuhiro. Adiponectin Inhibits LPS-Induced HMGB1 Release through an AMP Kinase and Heme Oxygenase-1-Dependent Pathway in RAW 264 Macrophage Cells. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111116
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111116
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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