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Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury
المؤلفون المشاركون
Brickler, Thomas
Gresham, Kisha
Meza, Armand
Coutermarsh-Ott, Sheryl
Williams, Tere M.
Rothschild, Daniel E.
Allen, Irving C.
Theus, Michelle H.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Traumatic brain injury (TBI) elicits the immediate production of proinflammatory cytokines which participate in regulating the immune response.
While the mechanisms of adaptive immunity in secondary injury are well characterized, the role of the innate response is unclear.
Recently, the NLR inflammasome has been shown to become activated following TBI, causing processing and release of interleukin-1β (IL-1β).
The inflammasome is a multiprotein complex consisting of nucleotide-binding domain and leucine-rich repeat containing proteins (NLR), caspase-1, and apoptosis-associated speck-like protein (ASC).
ASC is upregulated after TBI and is critical in coupling the proteins during complex formation resulting in IL-1β cleavage.
To directly test whether inflammasome activation contributes to acute TBI-induced damage, we assessed IL-1β, IL-18, and IL-6 expression, contusion volume, hippocampal cell death, and motor behavior recovery in Nlrp1 −/−, Asc −/−, and wild type mice after moderate controlled cortical impact (CCI) injury.
Although IL-1β expression is significantly attenuated in the cortex of Nlrp1 −/− and Asc −/− mice following CCI injury, no difference in motor recovery, cell death, or contusion volume is observed compared to wild type.
These findings indicate that inflammasome activation does not significantly contribute to acute neural injury in the murine model of moderate CCI injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brickler, Thomas& Gresham, Kisha& Meza, Armand& Coutermarsh-Ott, Sheryl& Williams, Tere M.& Rothschild, Daniel E.…[et al.]. 2016. Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111152
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brickler, Thomas…[et al.]. Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111152
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brickler, Thomas& Gresham, Kisha& Meza, Armand& Coutermarsh-Ott, Sheryl& Williams, Tere M.& Rothschild, Daniel E.…[et al.]. Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111152
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111152
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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