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Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury
Joint Authors
Brickler, Thomas
Gresham, Kisha
Meza, Armand
Coutermarsh-Ott, Sheryl
Williams, Tere M.
Rothschild, Daniel E.
Allen, Irving C.
Theus, Michelle H.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Traumatic brain injury (TBI) elicits the immediate production of proinflammatory cytokines which participate in regulating the immune response.
While the mechanisms of adaptive immunity in secondary injury are well characterized, the role of the innate response is unclear.
Recently, the NLR inflammasome has been shown to become activated following TBI, causing processing and release of interleukin-1β (IL-1β).
The inflammasome is a multiprotein complex consisting of nucleotide-binding domain and leucine-rich repeat containing proteins (NLR), caspase-1, and apoptosis-associated speck-like protein (ASC).
ASC is upregulated after TBI and is critical in coupling the proteins during complex formation resulting in IL-1β cleavage.
To directly test whether inflammasome activation contributes to acute TBI-induced damage, we assessed IL-1β, IL-18, and IL-6 expression, contusion volume, hippocampal cell death, and motor behavior recovery in Nlrp1 −/−, Asc −/−, and wild type mice after moderate controlled cortical impact (CCI) injury.
Although IL-1β expression is significantly attenuated in the cortex of Nlrp1 −/− and Asc −/− mice following CCI injury, no difference in motor recovery, cell death, or contusion volume is observed compared to wild type.
These findings indicate that inflammasome activation does not significantly contribute to acute neural injury in the murine model of moderate CCI injury.
American Psychological Association (APA)
Brickler, Thomas& Gresham, Kisha& Meza, Armand& Coutermarsh-Ott, Sheryl& Williams, Tere M.& Rothschild, Daniel E.…[et al.]. 2016. Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111152
Modern Language Association (MLA)
Brickler, Thomas…[et al.]. Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111152
American Medical Association (AMA)
Brickler, Thomas& Gresham, Kisha& Meza, Armand& Coutermarsh-Ott, Sheryl& Williams, Tere M.& Rothschild, Daniel E.…[et al.]. Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111152
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111152