mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections
المؤلفون المشاركون
Fang, Lijun
Tu, Huaijun
Guo, Wei
Wang, Shixuan
Xue, Ting
Yang, Fei
Zhang, Xiaoyan
Yang, Yazhi
Wan, Qian
Shi, Zhexin
Zhan, Xulong
Li, Jian
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-26
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The TSC1/2 heterodimer, a key upstream regulator of the mTOR, can inhibit the activation of mTOR, which plays a critical role in immune responses after bacterial infections.
Monocytes are an innate immune cell type that have been shown to be involved in bacteremia.
However, how the mTOR pathway is involved in the regulation of monocytes is largely unknown.
In our study, TSC1 KO mice and WT mice were infected with E.
coli.
When compared to WT mice, we found higher mortality, greater numbers of bacteria, decreased expression of coactivators in monocytes, increased numbers of Tregs, and decreased numbers of effector T cells in TSC1 KO mice.
Monocytes obtained from TSC1 KO mice produced more ROS, IL-6, IL-10, and TGF-β and less IL-1, IFN-γ, and TNF-α.
Taken together, our results suggest that the inhibited immune functioning in TSC1 KO mice is influenced by mTORC1 activation in monocytes.
The reduced expression of coactivators resulted in inhibited effector T cell proliferation.
mTORC1-activated monocytes are harmful during bacterial infections.
Therefore, inhibiting mTORC1 signaling through rapamycin administration could rescue the harmful aspects of an overactive immune response, and this knowledge provides a new direction for clinical therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fang, Lijun& Tu, Huaijun& Guo, Wei& Wang, Shixuan& Xue, Ting& Yang, Fei…[et al.]. 2016. mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111208
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fang, Lijun…[et al.]. mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections. Mediators of Inflammation No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1111208
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fang, Lijun& Tu, Huaijun& Guo, Wei& Wang, Shixuan& Xue, Ting& Yang, Fei…[et al.]. mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111208
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111208
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر