mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections
Joint Authors
Fang, Lijun
Tu, Huaijun
Guo, Wei
Wang, Shixuan
Xue, Ting
Yang, Fei
Zhang, Xiaoyan
Yang, Yazhi
Wan, Qian
Shi, Zhexin
Zhan, Xulong
Li, Jian
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The TSC1/2 heterodimer, a key upstream regulator of the mTOR, can inhibit the activation of mTOR, which plays a critical role in immune responses after bacterial infections.
Monocytes are an innate immune cell type that have been shown to be involved in bacteremia.
However, how the mTOR pathway is involved in the regulation of monocytes is largely unknown.
In our study, TSC1 KO mice and WT mice were infected with E.
coli.
When compared to WT mice, we found higher mortality, greater numbers of bacteria, decreased expression of coactivators in monocytes, increased numbers of Tregs, and decreased numbers of effector T cells in TSC1 KO mice.
Monocytes obtained from TSC1 KO mice produced more ROS, IL-6, IL-10, and TGF-β and less IL-1, IFN-γ, and TNF-α.
Taken together, our results suggest that the inhibited immune functioning in TSC1 KO mice is influenced by mTORC1 activation in monocytes.
The reduced expression of coactivators resulted in inhibited effector T cell proliferation.
mTORC1-activated monocytes are harmful during bacterial infections.
Therefore, inhibiting mTORC1 signaling through rapamycin administration could rescue the harmful aspects of an overactive immune response, and this knowledge provides a new direction for clinical therapy.
American Psychological Association (APA)
Fang, Lijun& Tu, Huaijun& Guo, Wei& Wang, Shixuan& Xue, Ting& Yang, Fei…[et al.]. 2016. mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111208
Modern Language Association (MLA)
Fang, Lijun…[et al.]. mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections. Mediators of Inflammation No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1111208
American Medical Association (AMA)
Fang, Lijun& Tu, Huaijun& Guo, Wei& Wang, Shixuan& Xue, Ting& Yang, Fei…[et al.]. mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111208