Effects of Standardised Fermented Papaya Gel on Clinical Symptoms, Inflammatory Cytokines, and Nitric Oxide Metabolites in Patients with Chronic Periodontitis: An Open Randomised Clinical Study
المؤلفون المشاركون
Chung Sheun Thai, Jeffrey
Korkina, Liudmila
Kharaeva, Zaira F.
Zhanimova, Lyana R.
Mustafaev, Magomet Sh.
Mayer, Wolfgang
Tiew Siok Tuan, Rebecca
De Luca, Chiara
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-10
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The clinical efficacy of topical administration of standardised fermented papaya gel (SFPG), known to have antioxidant and anti-inflammatory properties, versus conventional therapy was evaluated in a group of 84 patients with moderate-to-severe periodontitis, randomly assigned to control group ( n = 45 ) undergoing traditional pharmacologic/surgical protocols or to experimental group ( n = 39 ), additionally treated with intragingival pocket SFPG (7 g) applications (15 min daily for 10 days).
Patients undergoing SFPG treatment showed significant ( P < 0.05 ), durable improvement of three major clinical indices of disease severity: reduced bleeding (day 7), plaque and gingival conditions (day 14), and consistent gingival pocket depth reduction (day 45).
Proinflammatory nitric oxide metabolites reached normal values in plasma (day 14) and gingival crevicular fluid (GCF) at day 45 with SFPG applications compared to controls that did not reach normalisation.
Levels of highly increased proinflammatory (IL-1B, IL-6) and suppressed anti-inflammatory (IL-10) cytokines normalised in the SFPG group by days 14 (plasma) and 45 (GCF), but never in the control group.
Although not acting directly as antibiotic, SFPG acted in synergy with human granulocytes blocking adaptive catalase induction in S.
aureus in response to granulocyte-derived oxidative stress, thus enhancing intracellular bacterial killing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kharaeva, Zaira F.& Zhanimova, Lyana R.& Mustafaev, Magomet Sh.& De Luca, Chiara& Mayer, Wolfgang& Chung Sheun Thai, Jeffrey…[et al.]. 2016. Effects of Standardised Fermented Papaya Gel on Clinical Symptoms, Inflammatory Cytokines, and Nitric Oxide Metabolites in Patients with Chronic Periodontitis: An Open Randomised Clinical Study. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111299
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kharaeva, Zaira F.…[et al.]. Effects of Standardised Fermented Papaya Gel on Clinical Symptoms, Inflammatory Cytokines, and Nitric Oxide Metabolites in Patients with Chronic Periodontitis: An Open Randomised Clinical Study. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1111299
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kharaeva, Zaira F.& Zhanimova, Lyana R.& Mustafaev, Magomet Sh.& De Luca, Chiara& Mayer, Wolfgang& Chung Sheun Thai, Jeffrey…[et al.]. Effects of Standardised Fermented Papaya Gel on Clinical Symptoms, Inflammatory Cytokines, and Nitric Oxide Metabolites in Patients with Chronic Periodontitis: An Open Randomised Clinical Study. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111299
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111299
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر