Effects of Standardised Fermented Papaya Gel on Clinical Symptoms, Inflammatory Cytokines, and Nitric Oxide Metabolites in Patients with Chronic Periodontitis: An Open Randomised Clinical Study
Joint Authors
Chung Sheun Thai, Jeffrey
Korkina, Liudmila
Kharaeva, Zaira F.
Zhanimova, Lyana R.
Mustafaev, Magomet Sh.
Mayer, Wolfgang
Tiew Siok Tuan, Rebecca
De Luca, Chiara
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The clinical efficacy of topical administration of standardised fermented papaya gel (SFPG), known to have antioxidant and anti-inflammatory properties, versus conventional therapy was evaluated in a group of 84 patients with moderate-to-severe periodontitis, randomly assigned to control group ( n = 45 ) undergoing traditional pharmacologic/surgical protocols or to experimental group ( n = 39 ), additionally treated with intragingival pocket SFPG (7 g) applications (15 min daily for 10 days).
Patients undergoing SFPG treatment showed significant ( P < 0.05 ), durable improvement of three major clinical indices of disease severity: reduced bleeding (day 7), plaque and gingival conditions (day 14), and consistent gingival pocket depth reduction (day 45).
Proinflammatory nitric oxide metabolites reached normal values in plasma (day 14) and gingival crevicular fluid (GCF) at day 45 with SFPG applications compared to controls that did not reach normalisation.
Levels of highly increased proinflammatory (IL-1B, IL-6) and suppressed anti-inflammatory (IL-10) cytokines normalised in the SFPG group by days 14 (plasma) and 45 (GCF), but never in the control group.
Although not acting directly as antibiotic, SFPG acted in synergy with human granulocytes blocking adaptive catalase induction in S.
aureus in response to granulocyte-derived oxidative stress, thus enhancing intracellular bacterial killing.
American Psychological Association (APA)
Kharaeva, Zaira F.& Zhanimova, Lyana R.& Mustafaev, Magomet Sh.& De Luca, Chiara& Mayer, Wolfgang& Chung Sheun Thai, Jeffrey…[et al.]. 2016. Effects of Standardised Fermented Papaya Gel on Clinical Symptoms, Inflammatory Cytokines, and Nitric Oxide Metabolites in Patients with Chronic Periodontitis: An Open Randomised Clinical Study. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111299
Modern Language Association (MLA)
Kharaeva, Zaira F.…[et al.]. Effects of Standardised Fermented Papaya Gel on Clinical Symptoms, Inflammatory Cytokines, and Nitric Oxide Metabolites in Patients with Chronic Periodontitis: An Open Randomised Clinical Study. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1111299
American Medical Association (AMA)
Kharaeva, Zaira F.& Zhanimova, Lyana R.& Mustafaev, Magomet Sh.& De Luca, Chiara& Mayer, Wolfgang& Chung Sheun Thai, Jeffrey…[et al.]. Effects of Standardised Fermented Papaya Gel on Clinical Symptoms, Inflammatory Cytokines, and Nitric Oxide Metabolites in Patients with Chronic Periodontitis: An Open Randomised Clinical Study. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111299