Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis
المؤلفون المشاركون
Desbiens, Louisane
Lapointe, Catherine
Gharagozloo, Marjan
Mahmoud, Shaimaa
Pejler, Gunnar
Gris, Denis
D’Orléans-Juste, Pedro
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Experimental autoimmune encephalomyelitis (EAE) is a mouse model that reproduces cardinal signs of clinical, histopathological, and immunological features found in Multiple Sclerosis (MS).
Mast cells are suggested to be involved in the main inflammatory phases occurring during EAE development, possibly by secreting several autacoids and proteases.
Among the latter, the chymase mouse mast cell protease 4 (mMCP-4) can contribute to the inflammatory response by producing endothelin-1 (ET-1).
The aim of this study was to determine the impact of mMCP-4 on acute inflammatory stages in EAE.
C57BL/6 wild type (WT) or mMCP-4 knockout (KO) mice were immunized with M O G 35 – 55 plus complete Freund’s adjuvant followed by pertussis toxin.
Immunized WT mice presented an initial acute phase characterized by progressive increases in clinical score, which were significantly reduced in mMCP-4 KO mice.
In addition, higher levels of spinal myelin were found in mMCP-4 KO as compared with WT mice.
Finally, whereas EAE triggered significant increases in brain levels of mMCP-4 mRNA and immunoreactive ET-1 in WT mice, the latter peptide was reduced to basal levels in mMCP-4 KO congeners.
Together, the present study supports a role for mMCP-4 in the early inflammatory phases of the disease in a mouse model of MS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Desbiens, Louisane& Lapointe, Catherine& Gharagozloo, Marjan& Mahmoud, Shaimaa& Pejler, Gunnar& Gris, Denis…[et al.]. 2016. Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111328
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Desbiens, Louisane…[et al.]. Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111328
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Desbiens, Louisane& Lapointe, Catherine& Gharagozloo, Marjan& Mahmoud, Shaimaa& Pejler, Gunnar& Gris, Denis…[et al.]. Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111328
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111328
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر