Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis
Joint Authors
Desbiens, Louisane
Lapointe, Catherine
Gharagozloo, Marjan
Mahmoud, Shaimaa
Pejler, Gunnar
Gris, Denis
D’Orléans-Juste, Pedro
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Experimental autoimmune encephalomyelitis (EAE) is a mouse model that reproduces cardinal signs of clinical, histopathological, and immunological features found in Multiple Sclerosis (MS).
Mast cells are suggested to be involved in the main inflammatory phases occurring during EAE development, possibly by secreting several autacoids and proteases.
Among the latter, the chymase mouse mast cell protease 4 (mMCP-4) can contribute to the inflammatory response by producing endothelin-1 (ET-1).
The aim of this study was to determine the impact of mMCP-4 on acute inflammatory stages in EAE.
C57BL/6 wild type (WT) or mMCP-4 knockout (KO) mice were immunized with M O G 35 – 55 plus complete Freund’s adjuvant followed by pertussis toxin.
Immunized WT mice presented an initial acute phase characterized by progressive increases in clinical score, which were significantly reduced in mMCP-4 KO mice.
In addition, higher levels of spinal myelin were found in mMCP-4 KO as compared with WT mice.
Finally, whereas EAE triggered significant increases in brain levels of mMCP-4 mRNA and immunoreactive ET-1 in WT mice, the latter peptide was reduced to basal levels in mMCP-4 KO congeners.
Together, the present study supports a role for mMCP-4 in the early inflammatory phases of the disease in a mouse model of MS.
American Psychological Association (APA)
Desbiens, Louisane& Lapointe, Catherine& Gharagozloo, Marjan& Mahmoud, Shaimaa& Pejler, Gunnar& Gris, Denis…[et al.]. 2016. Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111328
Modern Language Association (MLA)
Desbiens, Louisane…[et al.]. Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111328
American Medical Association (AMA)
Desbiens, Louisane& Lapointe, Catherine& Gharagozloo, Marjan& Mahmoud, Shaimaa& Pejler, Gunnar& Gris, Denis…[et al.]. Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111328