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Compensation through Functional Hyperconnectivity: A Longitudinal Connectome Assessment of Mild Traumatic Brain Injury
المؤلفون المشاركون
Liu, Tianming
Iraji, Armin
Chen, Hanbo
Wiseman, Natalie
Welch, Robert D.
O’Neil, Brian J.
Kou, Zhifeng
Haacke, E. Mark
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Mild traumatic brain injury (mTBI) is a major public health concern.
Functional MRI has reported alterations in several brain networks following mTBI.
However, the connectome-scale brain network changes are still unknown.
In this study, sixteen mTBI patients were prospectively recruited from an emergency department and followed up at 4–6 weeks after injury.
Twenty-four healthy controls were also scanned twice with the same time interval.
Three hundred fifty-eight brain landmarks that preserve structural and functional correspondence of brain networks across individuals were used to investigate longitudinal brain connectivity.
Network-based statistic (NBS) analysis did not find significant difference in the group-by-time interaction and time effects.
However, 258 functional pairs show group differences in which mTBI patients have higher functional connectivity.
Meta-analysis showed that “Action” and “Cognition” are the most affected functional domains.
Categorization of connectomic signatures using multiview group-wise cluster analysis identified two patterns of functional hyperconnectivity among mTBI patients: (I) between the posterior cingulate cortex and the association areas of the brain and (II) between the occipital and the frontal lobes of the brain.
Our results demonstrate that brain concussion renders connectome-scale brain network connectivity changes, and the brain tends to be hyperactivated to compensate the pathophysiological disturbances.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Iraji, Armin& Chen, Hanbo& Wiseman, Natalie& Welch, Robert D.& O’Neil, Brian J.& Haacke, E. Mark…[et al.]. 2015. Compensation through Functional Hyperconnectivity: A Longitudinal Connectome Assessment of Mild Traumatic Brain Injury. Neural Plasticity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113125
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Iraji, Armin…[et al.]. Compensation through Functional Hyperconnectivity: A Longitudinal Connectome Assessment of Mild Traumatic Brain Injury. Neural Plasticity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113125
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Iraji, Armin& Chen, Hanbo& Wiseman, Natalie& Welch, Robert D.& O’Neil, Brian J.& Haacke, E. Mark…[et al.]. Compensation through Functional Hyperconnectivity: A Longitudinal Connectome Assessment of Mild Traumatic Brain Injury. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113125
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113125
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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