Compensation through Functional Hyperconnectivity: A Longitudinal Connectome Assessment of Mild Traumatic Brain Injury
Joint Authors
Liu, Tianming
Iraji, Armin
Chen, Hanbo
Wiseman, Natalie
Welch, Robert D.
O’Neil, Brian J.
Kou, Zhifeng
Haacke, E. Mark
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Mild traumatic brain injury (mTBI) is a major public health concern.
Functional MRI has reported alterations in several brain networks following mTBI.
However, the connectome-scale brain network changes are still unknown.
In this study, sixteen mTBI patients were prospectively recruited from an emergency department and followed up at 4–6 weeks after injury.
Twenty-four healthy controls were also scanned twice with the same time interval.
Three hundred fifty-eight brain landmarks that preserve structural and functional correspondence of brain networks across individuals were used to investigate longitudinal brain connectivity.
Network-based statistic (NBS) analysis did not find significant difference in the group-by-time interaction and time effects.
However, 258 functional pairs show group differences in which mTBI patients have higher functional connectivity.
Meta-analysis showed that “Action” and “Cognition” are the most affected functional domains.
Categorization of connectomic signatures using multiview group-wise cluster analysis identified two patterns of functional hyperconnectivity among mTBI patients: (I) between the posterior cingulate cortex and the association areas of the brain and (II) between the occipital and the frontal lobes of the brain.
Our results demonstrate that brain concussion renders connectome-scale brain network connectivity changes, and the brain tends to be hyperactivated to compensate the pathophysiological disturbances.
American Psychological Association (APA)
Iraji, Armin& Chen, Hanbo& Wiseman, Natalie& Welch, Robert D.& O’Neil, Brian J.& Haacke, E. Mark…[et al.]. 2015. Compensation through Functional Hyperconnectivity: A Longitudinal Connectome Assessment of Mild Traumatic Brain Injury. Neural Plasticity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113125
Modern Language Association (MLA)
Iraji, Armin…[et al.]. Compensation through Functional Hyperconnectivity: A Longitudinal Connectome Assessment of Mild Traumatic Brain Injury. Neural Plasticity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113125
American Medical Association (AMA)
Iraji, Armin& Chen, Hanbo& Wiseman, Natalie& Welch, Robert D.& O’Neil, Brian J.& Haacke, E. Mark…[et al.]. Compensation through Functional Hyperconnectivity: A Longitudinal Connectome Assessment of Mild Traumatic Brain Injury. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113125