Early Transcriptional Changes Induced by Wntβ-Catenin Signaling in Hippocampal Neurons
المؤلفون المشاركون
Pérez-Palma, Eduardo
Andrade, Víctor
Caracci, Mario O.
Bustos, Bernabé I.
Villaman, Camilo
Medina, Matías A.
Ávila, Miguel E.
Ugarte, Giorgia D.
De Ferrari, Giancarlo V.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Wnt/β-catenin signaling modulates brain development and function and its deregulation underlies pathological changes occurring in neurodegenerative and neurodevelopmental disorders.
Since one of the main effects of Wnt/β-catenin signaling is the modulation of target genes, in the present work we examined global transcriptional changes induced by short-term Wnt3a treatment (4 h) in primary cultures of rat hippocampal neurons.
RNAseq experiments allowed the identification of 170 differentially expressed genes, including known Wnt/β-catenin target genes such as Notum, Axin2, and Lef1, as well as novel potential candidates Fam84a, Stk32a, and Itga9.
Main biological processes enriched with differentially expressed genes included neural precursor (GO:0061364, p-adjusted = 2.5 × 10−7), forebrain development (GO:0030900, p-adjusted = 7.3 × 10−7), and stem cell differentiation (GO:0048863 p-adjusted = 7.3 × 10−7).
Likewise, following activation of the signaling cascade, the expression of a significant number of genes with transcription factor activity (GO:0043565, p-adjusted = 4.1 × 10−6) was induced.
We also studied molecular networks enriched upon Wnt3a activation and detected three highly significant expression modules involved in glycerolipid metabolic process (GO:0046486, p-adjusted = 4.5 × 10−19), learning or memory (GO:0007611, p-adjusted = 4.0 × 10−5), and neurotransmitter secretion (GO:0007269, p-adjusted = 5.3 × 10−12).
Our results indicate that Wnt/β-catenin mediated transcription controls multiple biological processes related to neuronal structure and activity that are affected in synaptic dysfunction disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pérez-Palma, Eduardo& Andrade, Víctor& Caracci, Mario O.& Bustos, Bernabé I.& Villaman, Camilo& Medina, Matías A.…[et al.]. 2016. Early Transcriptional Changes Induced by Wntβ-Catenin Signaling in Hippocampal Neurons. Neural Plasticity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113153
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pérez-Palma, Eduardo…[et al.]. Early Transcriptional Changes Induced by Wntβ-Catenin Signaling in Hippocampal Neurons. Neural Plasticity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113153
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pérez-Palma, Eduardo& Andrade, Víctor& Caracci, Mario O.& Bustos, Bernabé I.& Villaman, Camilo& Medina, Matías A.…[et al.]. Early Transcriptional Changes Induced by Wntβ-Catenin Signaling in Hippocampal Neurons. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113153
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113153
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر