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Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer’s Disease
المؤلفون المشاركون
Han, Ying
Li, Kuncheng
Li, Yuxia
Yu, Yang
Wang, Xiaoni
Li, Yongqiu
Sun, Yu
Sheng, Can
Li, Hongyan
Li, Xuanyu
Chen, Guanqun
Hu, Xiaochen
Jing, Bin
Wang, Defeng
Jessen, Frank
Xia, Mingrui
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Individuals diagnosed with mild cognitive impairment (MCI) are at high risk of transition to Alzheimer’s disease (AD).
However, little is known about functional characteristics of the conversion from MCI to AD.
Resting-state functional magnetic resonance imaging was performed in 25 AD patients, 31 MCI patients, and 42 well-matched normal controls at baseline.
Twenty-one of the 31 MCI patients converted to AD at approximately 24 months of follow-up.
Functional connectivity strength (FCS) and seed-based functional connectivity analyses were used to assess the functional differences among the groups.
Compared to controls, subjects with MCI and AD showed decreased FCS in the default-mode network and the occipital cortex.
Importantly, the FCS of the left angular gyrus and middle occipital gyrus was significantly lower in MCI-converters as compared with MCI-nonconverters.
Significantly decreased functional connectivity was found in MCI-converters compared to nonconverters between the left angular gyrus and bilateral inferior parietal lobules, dorsolateral prefrontal and lateral temporal cortices, and the left middle occipital gyrus and right middle occipital gyri.
We demonstrated gradual but progressive functional changes during a median 2-year interval in patients converting from MCI to AD, which might serve as early indicators for the dysfunction and progression in the early stage of AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yuxia& Wang, Xiaoni& Li, Yongqiu& Sun, Yu& Sheng, Can& Li, Hongyan…[et al.]. 2015. Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer’s Disease. Neural Plasticity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113155
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yuxia…[et al.]. Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer’s Disease. Neural Plasticity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113155
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yuxia& Wang, Xiaoni& Li, Yongqiu& Sun, Yu& Sheng, Can& Li, Hongyan…[et al.]. Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer’s Disease. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113155
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113155
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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