Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer’s Disease
Joint Authors
Han, Ying
Li, Kuncheng
Li, Yuxia
Yu, Yang
Wang, Xiaoni
Li, Yongqiu
Sun, Yu
Sheng, Can
Li, Hongyan
Li, Xuanyu
Chen, Guanqun
Hu, Xiaochen
Jing, Bin
Wang, Defeng
Jessen, Frank
Xia, Mingrui
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Individuals diagnosed with mild cognitive impairment (MCI) are at high risk of transition to Alzheimer’s disease (AD).
However, little is known about functional characteristics of the conversion from MCI to AD.
Resting-state functional magnetic resonance imaging was performed in 25 AD patients, 31 MCI patients, and 42 well-matched normal controls at baseline.
Twenty-one of the 31 MCI patients converted to AD at approximately 24 months of follow-up.
Functional connectivity strength (FCS) and seed-based functional connectivity analyses were used to assess the functional differences among the groups.
Compared to controls, subjects with MCI and AD showed decreased FCS in the default-mode network and the occipital cortex.
Importantly, the FCS of the left angular gyrus and middle occipital gyrus was significantly lower in MCI-converters as compared with MCI-nonconverters.
Significantly decreased functional connectivity was found in MCI-converters compared to nonconverters between the left angular gyrus and bilateral inferior parietal lobules, dorsolateral prefrontal and lateral temporal cortices, and the left middle occipital gyrus and right middle occipital gyri.
We demonstrated gradual but progressive functional changes during a median 2-year interval in patients converting from MCI to AD, which might serve as early indicators for the dysfunction and progression in the early stage of AD.
American Psychological Association (APA)
Li, Yuxia& Wang, Xiaoni& Li, Yongqiu& Sun, Yu& Sheng, Can& Li, Hongyan…[et al.]. 2015. Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer’s Disease. Neural Plasticity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113155
Modern Language Association (MLA)
Li, Yuxia…[et al.]. Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer’s Disease. Neural Plasticity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113155
American Medical Association (AMA)
Li, Yuxia& Wang, Xiaoni& Li, Yongqiu& Sun, Yu& Sheng, Can& Li, Hongyan…[et al.]. Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer’s Disease. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113155