Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait
المؤلفون المشاركون
Manzanedo, Carmen
Rodríguez-Arias, Marta
Miñarro, José
Roger-Sánchez, C.
Vilanova, I.
Revert, N.
Aguilar, María A.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-31
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Adolescent exposure to cannabinoids enhances the behavioural effects of cocaine, and high novelty-seeking trait predicts greater sensitivity to the conditioned place preference (CPP) induced by this drug.
Our aim was to evaluate the influence of novelty-seeking on the effects of adolescent cannabinoid exposure.
Adolescent male mice were classified as high or low novelty seekers (HNS and LNS) in the hole-board test.
First, we evaluated the CPP induced by the cannabinoid agonist WIN 55212-2 (0.05 and 0.075 mg/kg, i.p.) in HNS and LNS mice.
Then, HNS and LNS mice were pretreated i.p.
with vehicle, WIN 55212-2 (0.1 mg/kg), or cannabinoid antagonist rimonabant (1 mg/kg) and were subsequently conditioned with WIN 55212-2 (0.05 mg/kg, i.p.) or cocaine (1 or 6 mg/kg, i.p.).
Only HNS mice conditioned with the 0.075 mg/kg dose acquired CPP with WIN 55212-2.
Adolescent exposure to this cannabinoid agonist increased the rewarding effects of 1 mg/kg of cocaine in both HNS and LNS mice, and in HNS mice it also increased the reinstating effect of a low dose of cocaine.
Our results endorse a role for individual differences such as a higher propensity for sensation-seeking in the development of addiction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rodríguez-Arias, Marta& Roger-Sánchez, C.& Vilanova, I.& Revert, N.& Manzanedo, Carmen& Miñarro, José…[et al.]. 2015. Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait. Neural Plasticity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113229
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rodríguez-Arias, Marta…[et al.]. Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait. Neural Plasticity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113229
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rodríguez-Arias, Marta& Roger-Sánchez, C.& Vilanova, I.& Revert, N.& Manzanedo, Carmen& Miñarro, José…[et al.]. Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113229
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113229
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر