Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait
Joint Authors
Manzanedo, Carmen
Rodríguez-Arias, Marta
Miñarro, José
Roger-Sánchez, C.
Vilanova, I.
Revert, N.
Aguilar, María A.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Adolescent exposure to cannabinoids enhances the behavioural effects of cocaine, and high novelty-seeking trait predicts greater sensitivity to the conditioned place preference (CPP) induced by this drug.
Our aim was to evaluate the influence of novelty-seeking on the effects of adolescent cannabinoid exposure.
Adolescent male mice were classified as high or low novelty seekers (HNS and LNS) in the hole-board test.
First, we evaluated the CPP induced by the cannabinoid agonist WIN 55212-2 (0.05 and 0.075 mg/kg, i.p.) in HNS and LNS mice.
Then, HNS and LNS mice were pretreated i.p.
with vehicle, WIN 55212-2 (0.1 mg/kg), or cannabinoid antagonist rimonabant (1 mg/kg) and were subsequently conditioned with WIN 55212-2 (0.05 mg/kg, i.p.) or cocaine (1 or 6 mg/kg, i.p.).
Only HNS mice conditioned with the 0.075 mg/kg dose acquired CPP with WIN 55212-2.
Adolescent exposure to this cannabinoid agonist increased the rewarding effects of 1 mg/kg of cocaine in both HNS and LNS mice, and in HNS mice it also increased the reinstating effect of a low dose of cocaine.
Our results endorse a role for individual differences such as a higher propensity for sensation-seeking in the development of addiction.
American Psychological Association (APA)
Rodríguez-Arias, Marta& Roger-Sánchez, C.& Vilanova, I.& Revert, N.& Manzanedo, Carmen& Miñarro, José…[et al.]. 2015. Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait. Neural Plasticity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113229
Modern Language Association (MLA)
Rodríguez-Arias, Marta…[et al.]. Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait. Neural Plasticity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113229
American Medical Association (AMA)
Rodríguez-Arias, Marta& Roger-Sánchez, C.& Vilanova, I.& Revert, N.& Manzanedo, Carmen& Miñarro, José…[et al.]. Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113229