Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity
المؤلفون المشاركون
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-25
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD) is an irreversible brain disorder characterized by progressive cognitive decline and neurodegeneration of brain regions that are crucial for learning and memory.
Although intracellular neurofibrillary tangles and extracellular senile plaques, composed of insoluble amyloid-β (Aβ) peptides, have been the hallmarks of postmortem AD brains, memory impairment in early AD correlates better with pathological accumulation of soluble Aβ oligomers and persistent weakening of excitatory synaptic strength, which is demonstrated by inhibition of long-term potentiation, enhancement of long-term depression, and loss of synapses.
However, current, approved interventions aiming to reduce Aβ levels have failed to retard disease progression; this has led to a pressing need to identify and target alternative pathogenic mechanisms of AD.
Recently, it has been suggested that the disruption of Hebbian synaptic plasticity in AD is due to aberrant metaplasticity, which is a form of homeostatic plasticity that tunes the magnitude and direction of future synaptic plasticity based on previous neuronal or synaptic activity.
This review examines emerging evidence for aberrant metaplasticity in AD.
Putative mechanisms underlying aberrant metaplasticity in AD will also be discussed.
We hope this review inspires future studies to test the extent to which these mechanisms contribute to the etiology of AD and offer therapeutic targets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jang, Sung-Soo& Chung, Hee Jung. 2016. Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity. Neural Plasticity،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1113291
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jang, Sung-Soo& Chung, Hee Jung. Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity. Neural Plasticity No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1113291
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jang, Sung-Soo& Chung, Hee Jung. Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1113291
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113291
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر