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Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-25
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is an irreversible brain disorder characterized by progressive cognitive decline and neurodegeneration of brain regions that are crucial for learning and memory.
Although intracellular neurofibrillary tangles and extracellular senile plaques, composed of insoluble amyloid-β (Aβ) peptides, have been the hallmarks of postmortem AD brains, memory impairment in early AD correlates better with pathological accumulation of soluble Aβ oligomers and persistent weakening of excitatory synaptic strength, which is demonstrated by inhibition of long-term potentiation, enhancement of long-term depression, and loss of synapses.
However, current, approved interventions aiming to reduce Aβ levels have failed to retard disease progression; this has led to a pressing need to identify and target alternative pathogenic mechanisms of AD.
Recently, it has been suggested that the disruption of Hebbian synaptic plasticity in AD is due to aberrant metaplasticity, which is a form of homeostatic plasticity that tunes the magnitude and direction of future synaptic plasticity based on previous neuronal or synaptic activity.
This review examines emerging evidence for aberrant metaplasticity in AD.
Putative mechanisms underlying aberrant metaplasticity in AD will also be discussed.
We hope this review inspires future studies to test the extent to which these mechanisms contribute to the etiology of AD and offer therapeutic targets.
American Psychological Association (APA)
Jang, Sung-Soo& Chung, Hee Jung. 2016. Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity. Neural Plasticity،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1113291
Modern Language Association (MLA)
Jang, Sung-Soo& Chung, Hee Jung. Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity. Neural Plasticity No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1113291
American Medical Association (AMA)
Jang, Sung-Soo& Chung, Hee Jung. Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1113291
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113291