Dendritic Spines in Depression: What We Learned from Animal Models
المؤلفون المشاركون
Ma, Xin-Ming
Qiao, Hui
Li, Ming-Xing
Xu, Chang
Chen, Hui-Bin
An, Shu-Cheng
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-26، 26ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-10
دولة النشر
مصر
عدد الصفحات
26
التخصصات الرئيسية
الملخص EN
Depression, a severe psychiatric disorder, has been studied for decades, but the underlying mechanisms still remain largely unknown.
Depression is closely associated with alterations in dendritic spine morphology and spine density.
Therefore, understanding dendritic spines is vital for uncovering the mechanisms underlying depression.
Several chronic stress models, including chronic restraint stress (CRS), chronic unpredictable mild stress (CUMS), and chronic social defeat stress (CSDS), have been used to recapitulate depression-like behaviors in rodents and study the underlying mechanisms.
In comparison with CRS, CUMS overcomes the stress habituation and has been widely used to model depression-like behaviors.
CSDS is one of the most frequently used models for depression, but it is limited to the study of male mice.
Generally, chronic stress causes dendritic atrophy and spine loss in the neurons of the hippocampus and prefrontal cortex.
Meanwhile, neurons of the amygdala and nucleus accumbens exhibit an increase in spine density.
These alterations induced by chronic stress are often accompanied by depression-like behaviors.
However, the underlying mechanisms are poorly understood.
This review summarizes our current understanding of the chronic stress-induced remodeling of dendritic spines in the hippocampus, prefrontal cortex, orbitofrontal cortex, amygdala, and nucleus accumbens and also discusses the putative underlying mechanisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qiao, Hui& Li, Ming-Xing& Xu, Chang& Chen, Hui-Bin& An, Shu-Cheng& Ma, Xin-Ming. 2016. Dendritic Spines in Depression: What We Learned from Animal Models. Neural Plasticity،Vol. 2016, no. 2016, pp.1-26.
https://search.emarefa.net/detail/BIM-1113300
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qiao, Hui…[et al.]. Dendritic Spines in Depression: What We Learned from Animal Models. Neural Plasticity No. 2016 (2016), pp.1-26.
https://search.emarefa.net/detail/BIM-1113300
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qiao, Hui& Li, Ming-Xing& Xu, Chang& Chen, Hui-Bin& An, Shu-Cheng& Ma, Xin-Ming. Dendritic Spines in Depression: What We Learned from Animal Models. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-26.
https://search.emarefa.net/detail/BIM-1113300
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113300
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر