Dendritic Spines in Depression: What We Learned from Animal Models
Joint Authors
Ma, Xin-Ming
Qiao, Hui
Li, Ming-Xing
Xu, Chang
Chen, Hui-Bin
An, Shu-Cheng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-26, 26 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-10
Country of Publication
Egypt
No. of Pages
26
Main Subjects
Abstract EN
Depression, a severe psychiatric disorder, has been studied for decades, but the underlying mechanisms still remain largely unknown.
Depression is closely associated with alterations in dendritic spine morphology and spine density.
Therefore, understanding dendritic spines is vital for uncovering the mechanisms underlying depression.
Several chronic stress models, including chronic restraint stress (CRS), chronic unpredictable mild stress (CUMS), and chronic social defeat stress (CSDS), have been used to recapitulate depression-like behaviors in rodents and study the underlying mechanisms.
In comparison with CRS, CUMS overcomes the stress habituation and has been widely used to model depression-like behaviors.
CSDS is one of the most frequently used models for depression, but it is limited to the study of male mice.
Generally, chronic stress causes dendritic atrophy and spine loss in the neurons of the hippocampus and prefrontal cortex.
Meanwhile, neurons of the amygdala and nucleus accumbens exhibit an increase in spine density.
These alterations induced by chronic stress are often accompanied by depression-like behaviors.
However, the underlying mechanisms are poorly understood.
This review summarizes our current understanding of the chronic stress-induced remodeling of dendritic spines in the hippocampus, prefrontal cortex, orbitofrontal cortex, amygdala, and nucleus accumbens and also discusses the putative underlying mechanisms.
American Psychological Association (APA)
Qiao, Hui& Li, Ming-Xing& Xu, Chang& Chen, Hui-Bin& An, Shu-Cheng& Ma, Xin-Ming. 2016. Dendritic Spines in Depression: What We Learned from Animal Models. Neural Plasticity،Vol. 2016, no. 2016, pp.1-26.
https://search.emarefa.net/detail/BIM-1113300
Modern Language Association (MLA)
Qiao, Hui…[et al.]. Dendritic Spines in Depression: What We Learned from Animal Models. Neural Plasticity No. 2016 (2016), pp.1-26.
https://search.emarefa.net/detail/BIM-1113300
American Medical Association (AMA)
Qiao, Hui& Li, Ming-Xing& Xu, Chang& Chen, Hui-Bin& An, Shu-Cheng& Ma, Xin-Ming. Dendritic Spines in Depression: What We Learned from Animal Models. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-26.
https://search.emarefa.net/detail/BIM-1113300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113300