KV1 and KV3 Potassium Channels Identified at Presynaptic Terminals of the Corticostriatal Synapses in Rat
المؤلفون المشاركون
Meneses, David
Vega, Ana V.
Torres-Cruz, Francisco Miguel
Barral, Jaime
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
In the last years it has been increasingly clear that K V -channel activity modulates neurotransmitter release.
The subcellular localization and composition of potassium channels are crucial to understanding its influence on neurotransmitter release.
To investigate the role of K V in corticostriatal synapses modulation, we combined extracellular recording of population-spike and pharmacological blockage with specific and nonspecific blockers to identify several families of K V channels.
We induced paired-pulse facilitation (PPF) and studied the changes in paired-pulse ratio (PPR) before and after the addition of specific K V blockers to determine whether particular K V subtypes were located pre- or postsynaptically.
Initially, the presence of K V channels was tested by exposing brain slices to tetraethylammonium or 4-aminopyridine; in both cases we observed a decrease in PPR that was dose dependent.
Further experiments with tityustoxin, margatoxin, hongotoxin, agitoxin, dendrotoxin, and BDS-I toxins all rendered a reduction in PPR.
In contrast heteropodatoxin and phrixotoxin had no effect.
Our results reveal that corticostriatal presynaptic K V channels have a complex stoichiometry, including heterologous combinations K V 1.1, K V 1.2, K V 1.3, and K V 1.6 isoforms, as well as K V 3.4, but not K V 4 channels.
The variety of K V channels offers a wide spectrum of possibilities to regulate neurotransmitter release, providing fine-tuning mechanisms to modulate synaptic strength.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meneses, David& Vega, Ana V.& Torres-Cruz, Francisco Miguel& Barral, Jaime. 2016. KV1 and KV3 Potassium Channels Identified at Presynaptic Terminals of the Corticostriatal Synapses in Rat. Neural Plasticity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113361
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meneses, David…[et al.]. KV1 and KV3 Potassium Channels Identified at Presynaptic Terminals of the Corticostriatal Synapses in Rat. Neural Plasticity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113361
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meneses, David& Vega, Ana V.& Torres-Cruz, Francisco Miguel& Barral, Jaime. KV1 and KV3 Potassium Channels Identified at Presynaptic Terminals of the Corticostriatal Synapses in Rat. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113361
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113361
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر