Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair
المؤلفون المشاركون
Leite Rodrigues de Oliveira, Alexandre
Perussi Biscola, Natalia
Politti Cartarozzi, Luciana
Ferreira Junior, Rui Seabra
Barraviera, B.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-29
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Brachial plexus lesion results in loss of motor and sensory function, being more harmful in the neonate.
Therefore, this study evaluated neuroprotection and regeneration after neonatal peripheral nerve coaptation with fibrin sealant.
Thus, P2 neonatal Lewis rats were divided into three groups: AX: sciatic nerve axotomy (SNA) without treatment; AX+FS: SNA followed by end-to-end coaptation with fibrin sealant derived from snake venom; AX+CFS: SNA followed by end-to-end coaptation with commercial fibrin sealant.
Results were analyzed 4, 8, and 12 weeks after lesion.
Astrogliosis, microglial reaction, and synapse preservation were evaluated by immunohistochemistry.
Neuronal survival, axonal regeneration, and ultrastructural changes at ventral spinal cord were also investigated.
Sensory-motor recovery was behaviorally studied.
Coaptation preserved synaptic covering on lesioned motoneurons and led to neuronal survival.
Reactive gliosis and microglial reaction decreased in the same groups (AX+FS, AX+CFS) at 4 weeks.
Regarding axonal regeneration, coaptation allowed recovery of greater number of myelinated fibers, with improved morphometric parameters.
Preservation of inhibitory synaptic terminals was accompanied by significant improvement in the motor as well as in the nociceptive recovery.
Overall, the present data suggest that acute repair of neonatal peripheral nerves with fibrin sealant results in neuroprotection and regeneration of motor and sensory axons.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Perussi Biscola, Natalia& Politti Cartarozzi, Luciana& Ferreira Junior, Rui Seabra& Barraviera, B.& Leite Rodrigues de Oliveira, Alexandre. 2016. Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair. Neural Plasticity،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1113371
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Perussi Biscola, Natalia…[et al.]. Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair. Neural Plasticity No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1113371
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Perussi Biscola, Natalia& Politti Cartarozzi, Luciana& Ferreira Junior, Rui Seabra& Barraviera, B.& Leite Rodrigues de Oliveira, Alexandre. Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1113371
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113371
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر