Increased Serum Levels of Tumor Necrosis Factor-Alpha, Resistin, and Visfatin in the Children with Autism Spectrum Disorders: A Case-Control Study
المؤلفون المشاركون
Ghaffari, Mohammad Ali
Mousavinejad, Elham
Riahi, Forough
Mousavinejad, Masoumeh
Afsharmanesh, Mohammad Reza
المصدر
Neurology Research International
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Autism spectrum disorders (ASDs) are complex disorders where the pathogenesis is not fully understood.
Several proinflammatory and immunoinflammatory disturbances have been observed in the etiology of ASD.
There is, however, limited knowledge on variations of adipokines in ASD.
The present study aimed to analyze the serum levels of resistin, visfatin, and tumor necrosis factor-alpha (TNF-α) in children with ASD in relation to body weight, gender, and ASD severity level.
Method.
In total, 30 children with ASD (mean age: 7.72±2.65 y; range; 4–12 y) and 30 healthy children (mean age: 8.4±2.66 y; range: 4–12 y), including males and females, were matched for age, gender, and body mass index (BMI).
Serum samples were collected, and visfatin, resistin, and TNF-α serum levels were measured using an enzyme-linked immunosorbent assay (ELISA) kit.
Result.
Serum visfatin, resistin, and TNF-α levels in children with ASD were significantly higher than that in the healthy patients (p<0.05).
Two significant correlations were found: a correlation between resistin and visfatin with TNF-α in children with ASD (R = 0.8 and R = 0.62, resp.) and a correlation between resistin and visfatin in children with ASD (R = 0.66).
Conclusion.
Higher TNF-α, resistin, and visfatin levels were found in children with ASD in comparison with controls, suggesting that elevated levels of serum proinflammatory agents may be implicated in the pathophysiology of ASD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghaffari, Mohammad Ali& Mousavinejad, Elham& Riahi, Forough& Mousavinejad, Masoumeh& Afsharmanesh, Mohammad Reza. 2016. Increased Serum Levels of Tumor Necrosis Factor-Alpha, Resistin, and Visfatin in the Children with Autism Spectrum Disorders: A Case-Control Study. Neurology Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113437
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghaffari, Mohammad Ali…[et al.]. Increased Serum Levels of Tumor Necrosis Factor-Alpha, Resistin, and Visfatin in the Children with Autism Spectrum Disorders: A Case-Control Study. Neurology Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1113437
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghaffari, Mohammad Ali& Mousavinejad, Elham& Riahi, Forough& Mousavinejad, Masoumeh& Afsharmanesh, Mohammad Reza. Increased Serum Levels of Tumor Necrosis Factor-Alpha, Resistin, and Visfatin in the Children with Autism Spectrum Disorders: A Case-Control Study. Neurology Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113437
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113437
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر