![](/images/graphics-bg.png)
Increased Serum Levels of Tumor Necrosis Factor-Alpha, Resistin, and Visfatin in the Children with Autism Spectrum Disorders: A Case-Control Study
Joint Authors
Ghaffari, Mohammad Ali
Mousavinejad, Elham
Riahi, Forough
Mousavinejad, Masoumeh
Afsharmanesh, Mohammad Reza
Source
Neurology Research International
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Autism spectrum disorders (ASDs) are complex disorders where the pathogenesis is not fully understood.
Several proinflammatory and immunoinflammatory disturbances have been observed in the etiology of ASD.
There is, however, limited knowledge on variations of adipokines in ASD.
The present study aimed to analyze the serum levels of resistin, visfatin, and tumor necrosis factor-alpha (TNF-α) in children with ASD in relation to body weight, gender, and ASD severity level.
Method.
In total, 30 children with ASD (mean age: 7.72±2.65 y; range; 4–12 y) and 30 healthy children (mean age: 8.4±2.66 y; range: 4–12 y), including males and females, were matched for age, gender, and body mass index (BMI).
Serum samples were collected, and visfatin, resistin, and TNF-α serum levels were measured using an enzyme-linked immunosorbent assay (ELISA) kit.
Result.
Serum visfatin, resistin, and TNF-α levels in children with ASD were significantly higher than that in the healthy patients (p<0.05).
Two significant correlations were found: a correlation between resistin and visfatin with TNF-α in children with ASD (R = 0.8 and R = 0.62, resp.) and a correlation between resistin and visfatin in children with ASD (R = 0.66).
Conclusion.
Higher TNF-α, resistin, and visfatin levels were found in children with ASD in comparison with controls, suggesting that elevated levels of serum proinflammatory agents may be implicated in the pathophysiology of ASD.
American Psychological Association (APA)
Ghaffari, Mohammad Ali& Mousavinejad, Elham& Riahi, Forough& Mousavinejad, Masoumeh& Afsharmanesh, Mohammad Reza. 2016. Increased Serum Levels of Tumor Necrosis Factor-Alpha, Resistin, and Visfatin in the Children with Autism Spectrum Disorders: A Case-Control Study. Neurology Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113437
Modern Language Association (MLA)
Ghaffari, Mohammad Ali…[et al.]. Increased Serum Levels of Tumor Necrosis Factor-Alpha, Resistin, and Visfatin in the Children with Autism Spectrum Disorders: A Case-Control Study. Neurology Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1113437
American Medical Association (AMA)
Ghaffari, Mohammad Ali& Mousavinejad, Elham& Riahi, Forough& Mousavinejad, Masoumeh& Afsharmanesh, Mohammad Reza. Increased Serum Levels of Tumor Necrosis Factor-Alpha, Resistin, and Visfatin in the Children with Autism Spectrum Disorders: A Case-Control Study. Neurology Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113437