Antioxidant and Antiplasmodial Activities of Bergenin and 11-O-Galloylbergenin Isolated from Mallotus philippensis
المؤلفون المشاركون
Khan, Hamayun
Amin, Hazrat
Ullah, Asad
Saba, Sumbal
Rafique, Jamal
Khan, Khalid
Ahmad, Nasir
Badshah, Syed Lal
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-22
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Two important biologically active compounds were isolated from Mallotus philippensis.
The isolated compounds were characterized using spectroanalytical techniques and found to be bergenin (1) and 11-O-galloylbergenin (2).
The in vitro antioxidant and antiplasmodial activities of the isolated compounds were determined.
For the antioxidant potential, three standard analytical protocols, namely, DPPH radical scavenging activity (RSA), reducing power assay (RPA), and total antioxidant capacity (TAC) assay, were adopted.
The results showed that compound 2 was found to be more potent antioxidant as compared to 1.
Fascinatingly, compound 2 displayed better EC50 results as compared to α -tocopherol while being comparable with ascorbic acid.
The antiplasmodial assay data showed that both the compound exhibited good activity against chloroquine sensitive strain of Plasmodium falciparum (D10) and IC50 values were found to be less than 8 μM.
The in silico molecular docking analyses were also performed for the determination of binding affinity of the isolated compounds using P.
falciparum proteins PfLDH and Pfg27.
The results showed that compound 2 has high docking score and binding affinity to both protein receptors as compared to compound 1.
The demonstrated biological potentials declared that compound 2 could be the better natural antioxidant and antiplasmodial candidate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khan, Hamayun& Amin, Hazrat& Ullah, Asad& Saba, Sumbal& Rafique, Jamal& Khan, Khalid…[et al.]. 2016. Antioxidant and Antiplasmodial Activities of Bergenin and 11-O-Galloylbergenin Isolated from Mallotus philippensis. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1113587
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khan, Hamayun…[et al.]. Antioxidant and Antiplasmodial Activities of Bergenin and 11-O-Galloylbergenin Isolated from Mallotus philippensis. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1113587
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khan, Hamayun& Amin, Hazrat& Ullah, Asad& Saba, Sumbal& Rafique, Jamal& Khan, Khalid…[et al.]. Antioxidant and Antiplasmodial Activities of Bergenin and 11-O-Galloylbergenin Isolated from Mallotus philippensis. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1113587
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113587
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر