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Antioxidant and Antiplasmodial Activities of Bergenin and 11-O-Galloylbergenin Isolated from Mallotus philippensis
Joint Authors
Khan, Hamayun
Amin, Hazrat
Ullah, Asad
Saba, Sumbal
Rafique, Jamal
Khan, Khalid
Ahmad, Nasir
Badshah, Syed Lal
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Two important biologically active compounds were isolated from Mallotus philippensis.
The isolated compounds were characterized using spectroanalytical techniques and found to be bergenin (1) and 11-O-galloylbergenin (2).
The in vitro antioxidant and antiplasmodial activities of the isolated compounds were determined.
For the antioxidant potential, three standard analytical protocols, namely, DPPH radical scavenging activity (RSA), reducing power assay (RPA), and total antioxidant capacity (TAC) assay, were adopted.
The results showed that compound 2 was found to be more potent antioxidant as compared to 1.
Fascinatingly, compound 2 displayed better EC50 results as compared to α -tocopherol while being comparable with ascorbic acid.
The antiplasmodial assay data showed that both the compound exhibited good activity against chloroquine sensitive strain of Plasmodium falciparum (D10) and IC50 values were found to be less than 8 μM.
The in silico molecular docking analyses were also performed for the determination of binding affinity of the isolated compounds using P.
falciparum proteins PfLDH and Pfg27.
The results showed that compound 2 has high docking score and binding affinity to both protein receptors as compared to compound 1.
The demonstrated biological potentials declared that compound 2 could be the better natural antioxidant and antiplasmodial candidate.
American Psychological Association (APA)
Khan, Hamayun& Amin, Hazrat& Ullah, Asad& Saba, Sumbal& Rafique, Jamal& Khan, Khalid…[et al.]. 2016. Antioxidant and Antiplasmodial Activities of Bergenin and 11-O-Galloylbergenin Isolated from Mallotus philippensis. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1113587
Modern Language Association (MLA)
Khan, Hamayun…[et al.]. Antioxidant and Antiplasmodial Activities of Bergenin and 11-O-Galloylbergenin Isolated from Mallotus philippensis. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1113587
American Medical Association (AMA)
Khan, Hamayun& Amin, Hazrat& Ullah, Asad& Saba, Sumbal& Rafique, Jamal& Khan, Khalid…[et al.]. Antioxidant and Antiplasmodial Activities of Bergenin and 11-O-Galloylbergenin Isolated from Mallotus philippensis. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1113587
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113587