Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans
المؤلفون المشاركون
Suthammarak, Wichit
Numpraphrut, Pornpayom
Charoensakdi, Ratiya
Neungton, Neelobol
Tunrungruangtavee, Vachara
Jaisupa, Nattapon
Charoensak, Suwit
Moongkarndi, Primchanien
Muangpaisan, Weerasak
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Crude extract from the pericarp of the mangosteen (mangosteen extract [ME]) has exhibited several medicinal properties in both animal models and human cell lines.
Interestingly, the cytotoxic activities were always observed in nonpolar fraction of the extract whereas the potent antioxidant was often found in polar fraction.
Although it has been demonstrated that the polar fraction of ME exhibited the antioxidant activity, the safety of the polar fraction of ME has never been thoroughly investigated in humans.
In this study, we investigated the safety of oral administration of the polar fraction of ME in 11 healthy Thai volunteers.
During a 24-week period of the study, only minor and tolerable side effects were reported; no serious side effects were documented.
Blood chemistry studies also showed no liver damage or kidney dysfunction in all subjects.
We also demonstrated antioxidant property of the polar fraction of ME both in vitro and in vivo.
Interestingly, oral administration of the polar fraction of ME enhanced the antioxidant capability of red blood cells and decreased oxidative damage to proteins within red blood cells and whole blood.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Suthammarak, Wichit& Numpraphrut, Pornpayom& Charoensakdi, Ratiya& Neungton, Neelobol& Tunrungruangtavee, Vachara& Jaisupa, Nattapon…[et al.]. 2016. Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113603
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Suthammarak, Wichit…[et al.]. Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113603
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Suthammarak, Wichit& Numpraphrut, Pornpayom& Charoensakdi, Ratiya& Neungton, Neelobol& Tunrungruangtavee, Vachara& Jaisupa, Nattapon…[et al.]. Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113603
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113603
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر