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Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans
Joint Authors
Suthammarak, Wichit
Numpraphrut, Pornpayom
Charoensakdi, Ratiya
Neungton, Neelobol
Tunrungruangtavee, Vachara
Jaisupa, Nattapon
Charoensak, Suwit
Moongkarndi, Primchanien
Muangpaisan, Weerasak
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Crude extract from the pericarp of the mangosteen (mangosteen extract [ME]) has exhibited several medicinal properties in both animal models and human cell lines.
Interestingly, the cytotoxic activities were always observed in nonpolar fraction of the extract whereas the potent antioxidant was often found in polar fraction.
Although it has been demonstrated that the polar fraction of ME exhibited the antioxidant activity, the safety of the polar fraction of ME has never been thoroughly investigated in humans.
In this study, we investigated the safety of oral administration of the polar fraction of ME in 11 healthy Thai volunteers.
During a 24-week period of the study, only minor and tolerable side effects were reported; no serious side effects were documented.
Blood chemistry studies also showed no liver damage or kidney dysfunction in all subjects.
We also demonstrated antioxidant property of the polar fraction of ME both in vitro and in vivo.
Interestingly, oral administration of the polar fraction of ME enhanced the antioxidant capability of red blood cells and decreased oxidative damage to proteins within red blood cells and whole blood.
American Psychological Association (APA)
Suthammarak, Wichit& Numpraphrut, Pornpayom& Charoensakdi, Ratiya& Neungton, Neelobol& Tunrungruangtavee, Vachara& Jaisupa, Nattapon…[et al.]. 2016. Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113603
Modern Language Association (MLA)
Suthammarak, Wichit…[et al.]. Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113603
American Medical Association (AMA)
Suthammarak, Wichit& Numpraphrut, Pornpayom& Charoensakdi, Ratiya& Neungton, Neelobol& Tunrungruangtavee, Vachara& Jaisupa, Nattapon…[et al.]. Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113603