Altered Striatocerebellar Metabolism and Systemic Inflammation in Parkinson’s Disease
المؤلفون المشاركون
Lin, Wei-Che
Wang, Hung-Chen
Chen, Meng-Hsiang
Li, Shau-Hsuan
Chen, Hsiu-Ling
Tsai, Nai-Wen
Lu, Cheng-Hsien
Yu, Chiun-Chieh
Yang, I-Hsiao
Huang, Yung-Cheng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-01
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Parkinson’s disease (PD) is the most second common neurodegenerative movement disorder.
Neuroinflammation due to systemic inflammation and elevated oxidative stress is considered a major factor promoting the pathogenesis of PD, but the relationship of structural brain imaging parameters to clinical inflammatory markers has not been well studied.
Our aim was to evaluate the association of magnetic resonance spectroscopy (MRS) measures with inflammatory markers.
Blood samples were collected from 33 patients with newly diagnosed PD and 30 healthy volunteers.
MRS data including levels of N-acetylaspartate (NAA), creatine (Cre), and choline (Cho) were measured in the bilateral basal ganglia and cerebellum.
Inflammatory markers included plasma nuclear DNA, plasma mitochondrial DNA, and apoptotic leukocyte levels.
The Cho/Cre ratio in the dominant basal ganglion, the dominant basal ganglia to cerebellum ratios of two MRS parameters NAA/Cre and Cho/Cre, and levels of nuclear DNA, mitochondrial DNA, and apoptotic leukocytes were significantly different between PD patients and normal healthy volunteers.
Significant positive correlations were noted between MRS measures and inflammatory marker levels.
In conclusion, patients with PD seem to have abnormal levels of inflammatory markers in the peripheral circulation and deficits in MRS measures in the dominant basal ganglion and cerebellum.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Chiun-Chieh& Chen, Meng-Hsiang& Lu, Cheng-Hsien& Huang, Yung-Cheng& Chen, Hsiu-Ling& Tsai, Nai-Wen…[et al.]. 2016. Altered Striatocerebellar Metabolism and Systemic Inflammation in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113649
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Chiun-Chieh…[et al.]. Altered Striatocerebellar Metabolism and Systemic Inflammation in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113649
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Chiun-Chieh& Chen, Meng-Hsiang& Lu, Cheng-Hsien& Huang, Yung-Cheng& Chen, Hsiu-Ling& Tsai, Nai-Wen…[et al.]. Altered Striatocerebellar Metabolism and Systemic Inflammation in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113649
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113649
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر