Altered Striatocerebellar Metabolism and Systemic Inflammation in Parkinson’s Disease

Abstract EN

Parkinson’s disease (PD) is the most second common neurodegenerative movement disorder.

Neuroinflammation due to systemic inflammation and elevated oxidative stress is considered a major factor promoting the pathogenesis of PD, but the relationship of structural brain imaging parameters to clinical inflammatory markers has not been well studied.

Our aim was to evaluate the association of magnetic resonance spectroscopy (MRS) measures with inflammatory markers.

Blood samples were collected from 33 patients with newly diagnosed PD and 30 healthy volunteers.

MRS data including levels of N-acetylaspartate (NAA), creatine (Cre), and choline (Cho) were measured in the bilateral basal ganglia and cerebellum.

Inflammatory markers included plasma nuclear DNA, plasma mitochondrial DNA, and apoptotic leukocyte levels.

The Cho/Cre ratio in the dominant basal ganglion, the dominant basal ganglia to cerebellum ratios of two MRS parameters NAA/Cre and Cho/Cre, and levels of nuclear DNA, mitochondrial DNA, and apoptotic leukocytes were significantly different between PD patients and normal healthy volunteers.

Significant positive correlations were noted between MRS measures and inflammatory marker levels.

In conclusion, patients with PD seem to have abnormal levels of inflammatory markers in the peripheral circulation and deficits in MRS measures in the dominant basal ganglion and cerebellum.