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Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway
المؤلفون المشاركون
Hu, Min
Zou, Wei
Wang, Chun-Yan
Chen, Xi
Tan, Hui-Ying
Zeng, Hai-Ying
Zhang, Ping
Tang, Xiao-Qing
Gu, Hongfeng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Chronic unpredictable mild stress (CUMS) induces hippocampal oxidative stress.
H2S functions as a neuroprotectant against oxidative stress in brain.
We have previously shown the upregulatory effect of H2S on BDNF protein expression in the hippocampus of rats.
Therefore, we hypothesized that H2S prevents CUMS-generated oxidative stress by upregulation of BDNF-TrkB pathway.
We showed that NaHS (0.03 or 0.1 mmol/kg/day) ameliorates the level of hippocampal oxidative stress, including reduced levels of malondialdehyde (MDA) and 4-hydroxy-2-trans-nonenal (4-HNE), as well as increased level of glutathione (GSH) and activity of superoxide dismutase (SOD) in the hippocampus of CUMS-treated rats.
We also found that H2S upregulated the level of BDNF and p-TrkB protein in the hippocampus of CUMS rats.
Furthermore, inhibition of BDNF signaling by K252a, an inhibitor of the BDNF receptor TrkB, blocked the antioxidant effects of H2S on CUMS-induced hippocampal oxidative stress.
These results reveal the inhibitory role of H2S in CUMS-induced hippocampal oxidative stress, which is through upregulation of BDNF/TrkB pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Min& Zou, Wei& Wang, Chun-Yan& Chen, Xi& Tan, Hui-Ying& Zeng, Hai-Ying…[et al.]. 2016. Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113686
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Min…[et al.]. Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113686
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Min& Zou, Wei& Wang, Chun-Yan& Chen, Xi& Tan, Hui-Ying& Zeng, Hai-Ying…[et al.]. Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113686
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113686
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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