Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway
Joint Authors
Hu, Min
Zou, Wei
Wang, Chun-Yan
Chen, Xi
Tan, Hui-Ying
Zeng, Hai-Ying
Zhang, Ping
Tang, Xiao-Qing
Gu, Hongfeng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chronic unpredictable mild stress (CUMS) induces hippocampal oxidative stress.
H2S functions as a neuroprotectant against oxidative stress in brain.
We have previously shown the upregulatory effect of H2S on BDNF protein expression in the hippocampus of rats.
Therefore, we hypothesized that H2S prevents CUMS-generated oxidative stress by upregulation of BDNF-TrkB pathway.
We showed that NaHS (0.03 or 0.1 mmol/kg/day) ameliorates the level of hippocampal oxidative stress, including reduced levels of malondialdehyde (MDA) and 4-hydroxy-2-trans-nonenal (4-HNE), as well as increased level of glutathione (GSH) and activity of superoxide dismutase (SOD) in the hippocampus of CUMS-treated rats.
We also found that H2S upregulated the level of BDNF and p-TrkB protein in the hippocampus of CUMS rats.
Furthermore, inhibition of BDNF signaling by K252a, an inhibitor of the BDNF receptor TrkB, blocked the antioxidant effects of H2S on CUMS-induced hippocampal oxidative stress.
These results reveal the inhibitory role of H2S in CUMS-induced hippocampal oxidative stress, which is through upregulation of BDNF/TrkB pathway.
American Psychological Association (APA)
Hu, Min& Zou, Wei& Wang, Chun-Yan& Chen, Xi& Tan, Hui-Ying& Zeng, Hai-Ying…[et al.]. 2016. Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113686
Modern Language Association (MLA)
Hu, Min…[et al.]. Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113686
American Medical Association (AMA)
Hu, Min& Zou, Wei& Wang, Chun-Yan& Chen, Xi& Tan, Hui-Ying& Zeng, Hai-Ying…[et al.]. Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113686
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113686