ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis IschemiaReperfusion Injury
المؤلفون المشاركون
Bitto, Alessandra
Irrera, Natasha
Pisani, Antonina
Puzzolo, Domenico
Micali, Antonio
Rinaldi, Mariagrazia
Marini, Herbert
Arcoraci, Vincenzo
Crea, Giovanni
Trichilo, Vincenzo
Bruschetta, Daniele
Minutoli, Letteria
Squadrito, Francesco
Altavilla, Domenica
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Ischemia and reperfusion (I/R) causes a reduction in arterial blood supply to tissues, followed by the restoration of perfusion and consequent reoxygenation.
The reestablishment of blood flow triggers further damage to the ischemic tissue through reactive oxygen species (ROS) accumulation, interference with cellular ion homeostasis, and inflammatory responses to cell death.
In normal conditions, ROS mediate important beneficial responses.
When their production is prolonged or elevated, harmful events are observed with peculiar cellular changes.
In particular, during I/R, ROS stimulate tissue inflammation and induce NLRP3 inflammasome activation.
The mechanisms underlying the activation of NLRP3 are several and not completely elucidated.
It was recently shown that NLRP3 might sense directly the presence of ROS produced by normal or malfunctioning mitochondria or indirectly by other activators of NLRP3.
Aim of the present review is to describe the current knowledge on the role of NLRP3 in some organs (brain, heart, kidney, and testis) after I/R injury, with particular regard to the role played by ROS in its activation.
Furthermore, as no specific therapy for the prevention or treatment of the high mortality and morbidity associated with I/R is available, the state of the art of the development of novel therapeutic approaches is illustrated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Minutoli, Letteria& Puzzolo, Domenico& Rinaldi, Mariagrazia& Irrera, Natasha& Marini, Herbert& Arcoraci, Vincenzo…[et al.]. 2016. ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis IschemiaReperfusion Injury. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113689
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Minutoli, Letteria…[et al.]. ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis IschemiaReperfusion Injury. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113689
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Minutoli, Letteria& Puzzolo, Domenico& Rinaldi, Mariagrazia& Irrera, Natasha& Marini, Herbert& Arcoraci, Vincenzo…[et al.]. ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis IschemiaReperfusion Injury. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113689
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113689
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر