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ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis IschemiaReperfusion Injury
Joint Authors
Bitto, Alessandra
Irrera, Natasha
Pisani, Antonina
Puzzolo, Domenico
Micali, Antonio
Rinaldi, Mariagrazia
Marini, Herbert
Arcoraci, Vincenzo
Crea, Giovanni
Trichilo, Vincenzo
Bruschetta, Daniele
Minutoli, Letteria
Squadrito, Francesco
Altavilla, Domenica
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ischemia and reperfusion (I/R) causes a reduction in arterial blood supply to tissues, followed by the restoration of perfusion and consequent reoxygenation.
The reestablishment of blood flow triggers further damage to the ischemic tissue through reactive oxygen species (ROS) accumulation, interference with cellular ion homeostasis, and inflammatory responses to cell death.
In normal conditions, ROS mediate important beneficial responses.
When their production is prolonged or elevated, harmful events are observed with peculiar cellular changes.
In particular, during I/R, ROS stimulate tissue inflammation and induce NLRP3 inflammasome activation.
The mechanisms underlying the activation of NLRP3 are several and not completely elucidated.
It was recently shown that NLRP3 might sense directly the presence of ROS produced by normal or malfunctioning mitochondria or indirectly by other activators of NLRP3.
Aim of the present review is to describe the current knowledge on the role of NLRP3 in some organs (brain, heart, kidney, and testis) after I/R injury, with particular regard to the role played by ROS in its activation.
Furthermore, as no specific therapy for the prevention or treatment of the high mortality and morbidity associated with I/R is available, the state of the art of the development of novel therapeutic approaches is illustrated.
American Psychological Association (APA)
Minutoli, Letteria& Puzzolo, Domenico& Rinaldi, Mariagrazia& Irrera, Natasha& Marini, Herbert& Arcoraci, Vincenzo…[et al.]. 2016. ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis IschemiaReperfusion Injury. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113689
Modern Language Association (MLA)
Minutoli, Letteria…[et al.]. ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis IschemiaReperfusion Injury. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113689
American Medical Association (AMA)
Minutoli, Letteria& Puzzolo, Domenico& Rinaldi, Mariagrazia& Irrera, Natasha& Marini, Herbert& Arcoraci, Vincenzo…[et al.]. ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis IschemiaReperfusion Injury. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113689
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113689