![](/images/graphics-bg.png)
Advanced Glycation End Products Evolution after Pancreas-Kidney Transplantation: Plasmatic and Cutaneous Assessments
المؤلفون المشاركون
Oliveira, José C.
Vizcaíno, José Ramón
Gouveia, Carlos
Silva, Donzília
Noronha, Irene L.
Rodrigues, Anabela
Castro Henriques, António
Fonseca, Isabel
Martins, La Salete
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-05
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Diabetes mellitus leads to increased Advanced Glycation End Products (AGE) production, which has been associated with secondary diabetic complications.
Type 1 diabetic patients undergoing pancreas-kidney transplantation (SPKT) can restore normoglycemia and renal function, eventually decreasing AGE accumulation.
We aimed to prospectively study AGE evolution after SPKT.
Circulating AGE were assessed in 20 patients, at time 0 (T0), 3 months (T3), 6 months (T6), and 12 months (T12) after successful SPKT.
Global AGE and carboxymethyllysine (CML) were analyzed, as well as advanced oxidation protein products (AOPP).
Skin biopsies were obtained at T0 and T12.
Immunohistochemistry with anti-AGE antibody evaluated skin AGE deposition.
AGE mean values were 16.8±6.4 μg/mL at T0; 17.1±3.8 μg/mL at T3; 17.5±5.6 μg/mL at T6; and 16.0±5.2 μg/mL at T12.
CML mean values were 0.94±0.36 ng/mL at T0; 1.11±0.48 ng/mL at T3; 0.99±0.42 ng/mL at T6; and 0.78±0.38 ng/mL at T12.
AOPP mean values were 130.1±76.8 μMol/L at T0; 137.3±110.6 μMol/L at T3; 116.4±51.2 μMol/L at T6; and 106.4±57.9 μMol/L at T12.
CML variation was significant (P=0.022); AOPP variation was nearly significant (P=0.076).
Skin biopsies evolved mostly from a cytoplasmic diffuse to a peripheral interkeratinocytic immunoreaction pattern; in 7 cases, a reduction in AGE immunoreaction intensity was evident at T12.
In conclusion, glycoxidation markers decrease, plasmatic and on tissues, may start early after SPKT.
Studies with prolonged follow-up may confirm these data.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Martins, La Salete& Oliveira, José C.& Vizcaíno, José Ramón& Fonseca, Isabel& Gouveia, Carlos& Silva, Donzília…[et al.]. 2016. Advanced Glycation End Products Evolution after Pancreas-Kidney Transplantation: Plasmatic and Cutaneous Assessments. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113690
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Martins, La Salete…[et al.]. Advanced Glycation End Products Evolution after Pancreas-Kidney Transplantation: Plasmatic and Cutaneous Assessments. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113690
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Martins, La Salete& Oliveira, José C.& Vizcaíno, José Ramón& Fonseca, Isabel& Gouveia, Carlos& Silva, Donzília…[et al.]. Advanced Glycation End Products Evolution after Pancreas-Kidney Transplantation: Plasmatic and Cutaneous Assessments. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113690
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113690
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)