Advanced Glycation End Products Evolution after Pancreas-Kidney Transplantation: Plasmatic and Cutaneous Assessments
Joint Authors
Oliveira, José C.
Vizcaíno, José Ramón
Gouveia, Carlos
Silva, Donzília
Noronha, Irene L.
Rodrigues, Anabela
Castro Henriques, António
Fonseca, Isabel
Martins, La Salete
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diabetes mellitus leads to increased Advanced Glycation End Products (AGE) production, which has been associated with secondary diabetic complications.
Type 1 diabetic patients undergoing pancreas-kidney transplantation (SPKT) can restore normoglycemia and renal function, eventually decreasing AGE accumulation.
We aimed to prospectively study AGE evolution after SPKT.
Circulating AGE were assessed in 20 patients, at time 0 (T0), 3 months (T3), 6 months (T6), and 12 months (T12) after successful SPKT.
Global AGE and carboxymethyllysine (CML) were analyzed, as well as advanced oxidation protein products (AOPP).
Skin biopsies were obtained at T0 and T12.
Immunohistochemistry with anti-AGE antibody evaluated skin AGE deposition.
AGE mean values were 16.8±6.4 μg/mL at T0; 17.1±3.8 μg/mL at T3; 17.5±5.6 μg/mL at T6; and 16.0±5.2 μg/mL at T12.
CML mean values were 0.94±0.36 ng/mL at T0; 1.11±0.48 ng/mL at T3; 0.99±0.42 ng/mL at T6; and 0.78±0.38 ng/mL at T12.
AOPP mean values were 130.1±76.8 μMol/L at T0; 137.3±110.6 μMol/L at T3; 116.4±51.2 μMol/L at T6; and 106.4±57.9 μMol/L at T12.
CML variation was significant (P=0.022); AOPP variation was nearly significant (P=0.076).
Skin biopsies evolved mostly from a cytoplasmic diffuse to a peripheral interkeratinocytic immunoreaction pattern; in 7 cases, a reduction in AGE immunoreaction intensity was evident at T12.
In conclusion, glycoxidation markers decrease, plasmatic and on tissues, may start early after SPKT.
Studies with prolonged follow-up may confirm these data.
American Psychological Association (APA)
Martins, La Salete& Oliveira, José C.& Vizcaíno, José Ramón& Fonseca, Isabel& Gouveia, Carlos& Silva, Donzília…[et al.]. 2016. Advanced Glycation End Products Evolution after Pancreas-Kidney Transplantation: Plasmatic and Cutaneous Assessments. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113690
Modern Language Association (MLA)
Martins, La Salete…[et al.]. Advanced Glycation End Products Evolution after Pancreas-Kidney Transplantation: Plasmatic and Cutaneous Assessments. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113690
American Medical Association (AMA)
Martins, La Salete& Oliveira, José C.& Vizcaíno, José Ramón& Fonseca, Isabel& Gouveia, Carlos& Silva, Donzília…[et al.]. Advanced Glycation End Products Evolution after Pancreas-Kidney Transplantation: Plasmatic and Cutaneous Assessments. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113690