Possible Biomarkers in Blood for Crohn’s Disease: Oxidative Stress and MicroRNAs—Current Evidences and Further Aspects to Unravel
المؤلفون المشاركون
Moret-Tatay, Inés
Iborra, Marisa
Cerrillo, Elena
Tortosa, Luis
Nos, Pilar
Beltrán, Belén
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Crohn’s disease (CD) is an inflammatory disorder characterised by a transmural inflammation of the intestinal wall.
Although the physiopathology of the disease is not yet fully understood, it is clear that the immune response plays an important role in it.
This hyperreactive immune system is accompanied by the presence of unregulated reactive oxygen species (ROS).
These elements are modulated in normal conditions by different elements, including enzymes that function as antioxidant defences preventing the harmful effects of ROS.
However, in CD there is an imbalance between ROS production and these antioxidant elements, resulting in oxidative stress (OxS) phenomena.
In fact, now OxS is being considered more a potential etiological factor for Crohn’s disease rather than a concomitant effect in the disease.
The persistence of the OxS can also be influencing the evolution of the disease.
Furthermore, the epigenetic mechanisms, above all microRNAs, are being considered key elements in the pathogenesis of CD.
These elements and the presence of OxS have also been linked to several diseases.
We, therefore, describe in this review the most significant findings related to oxidative stress and microRNAs profiles in the peripheral blood of CD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moret-Tatay, Inés& Iborra, Marisa& Cerrillo, Elena& Tortosa, Luis& Nos, Pilar& Beltrán, Belén. 2015. Possible Biomarkers in Blood for Crohn’s Disease: Oxidative Stress and MicroRNAs—Current Evidences and Further Aspects to Unravel. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113692
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moret-Tatay, Inés…[et al.]. Possible Biomarkers in Blood for Crohn’s Disease: Oxidative Stress and MicroRNAs—Current Evidences and Further Aspects to Unravel. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113692
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moret-Tatay, Inés& Iborra, Marisa& Cerrillo, Elena& Tortosa, Luis& Nos, Pilar& Beltrán, Belén. Possible Biomarkers in Blood for Crohn’s Disease: Oxidative Stress and MicroRNAs—Current Evidences and Further Aspects to Unravel. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113692
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1113692
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر