Possible Biomarkers in Blood for Crohn’s Disease: Oxidative Stress and MicroRNAs—Current Evidences and Further Aspects to Unravel
Joint Authors
Moret-Tatay, Inés
Iborra, Marisa
Cerrillo, Elena
Tortosa, Luis
Nos, Pilar
Beltrán, Belén
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Crohn’s disease (CD) is an inflammatory disorder characterised by a transmural inflammation of the intestinal wall.
Although the physiopathology of the disease is not yet fully understood, it is clear that the immune response plays an important role in it.
This hyperreactive immune system is accompanied by the presence of unregulated reactive oxygen species (ROS).
These elements are modulated in normal conditions by different elements, including enzymes that function as antioxidant defences preventing the harmful effects of ROS.
However, in CD there is an imbalance between ROS production and these antioxidant elements, resulting in oxidative stress (OxS) phenomena.
In fact, now OxS is being considered more a potential etiological factor for Crohn’s disease rather than a concomitant effect in the disease.
The persistence of the OxS can also be influencing the evolution of the disease.
Furthermore, the epigenetic mechanisms, above all microRNAs, are being considered key elements in the pathogenesis of CD.
These elements and the presence of OxS have also been linked to several diseases.
We, therefore, describe in this review the most significant findings related to oxidative stress and microRNAs profiles in the peripheral blood of CD patients.
American Psychological Association (APA)
Moret-Tatay, Inés& Iborra, Marisa& Cerrillo, Elena& Tortosa, Luis& Nos, Pilar& Beltrán, Belén. 2015. Possible Biomarkers in Blood for Crohn’s Disease: Oxidative Stress and MicroRNAs—Current Evidences and Further Aspects to Unravel. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113692
Modern Language Association (MLA)
Moret-Tatay, Inés…[et al.]. Possible Biomarkers in Blood for Crohn’s Disease: Oxidative Stress and MicroRNAs—Current Evidences and Further Aspects to Unravel. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113692
American Medical Association (AMA)
Moret-Tatay, Inés& Iborra, Marisa& Cerrillo, Elena& Tortosa, Luis& Nos, Pilar& Beltrán, Belén. Possible Biomarkers in Blood for Crohn’s Disease: Oxidative Stress and MicroRNAs—Current Evidences and Further Aspects to Unravel. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113692